node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MYO1D | maea | ENSDARP00000067761 | ENSDARP00000070240 | Unconventional myosin-Id; Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in the formation of Kupffer's vesicle, an organ that functions as left-right organizer during embryogenesis. Plays a role in vesicular trafficking events that are required for normal lumen expansion of Kupffer's vesicle. Required for normal orientation of cilia in Kupffer's vesicle, and thus for normal, unidirectional circular flow and normal angular flow velocity, which then mediates asymmetric gene expression and left-right asymmetric developm [...] | E3 ubiquitin-protein transferase MAEA; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin- protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity). Plays a role in erythroblast maturati [...] | 0.515 |
MYO1D | pdlim2 | ENSDARP00000067761 | ENSDARP00000109858 | Unconventional myosin-Id; Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in the formation of Kupffer's vesicle, an organ that functions as left-right organizer during embryogenesis. Plays a role in vesicular trafficking events that are required for normal lumen expansion of Kupffer's vesicle. Required for normal orientation of cilia in Kupffer's vesicle, and thus for normal, unidirectional circular flow and normal angular flow velocity, which then mediates asymmetric gene expression and left-right asymmetric developm [...] | PDZ and LIM domain 2 (mystique). | 0.400 |
MYO1D | strbp | ENSDARP00000067761 | ENSDARP00000151771 | Unconventional myosin-Id; Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in the formation of Kupffer's vesicle, an organ that functions as left-right organizer during embryogenesis. Plays a role in vesicular trafficking events that are required for normal lumen expansion of Kupffer's vesicle. Required for normal orientation of cilia in Kupffer's vesicle, and thus for normal, unidirectional circular flow and normal angular flow velocity, which then mediates asymmetric gene expression and left-right asymmetric developm [...] | Spermatid perinuclear RNA-binding protein. | 0.513 |
MYO1D | twf1a | ENSDARP00000067761 | ENSDARP00000155344 | Unconventional myosin-Id; Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in the formation of Kupffer's vesicle, an organ that functions as left-right organizer during embryogenesis. Plays a role in vesicular trafficking events that are required for normal lumen expansion of Kupffer's vesicle. Required for normal orientation of cilia in Kupffer's vesicle, and thus for normal, unidirectional circular flow and normal angular flow velocity, which then mediates asymmetric gene expression and left-right asymmetric developm [...] | Twinfilin actin-binding protein 1a. | 0.578 |
acta1b | cap1 | ENSDARP00000058628 | ENSDARP00000020578 | Actin alpha 1, skeletal muscle b. | Adenylyl cyclase-associated protein; Belongs to the CAP family. | 0.618 |
acta1b | cap2 | ENSDARP00000058628 | ENSDARP00000139926 | Actin alpha 1, skeletal muscle b. | Adenylyl cyclase-associated protein; Belongs to the CAP family. | 0.670 |
acta1b | capzb | ENSDARP00000058628 | ENSDARP00000140899 | Actin alpha 1, skeletal muscle b. | F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. | 0.894 |
acta1b | twf1a | ENSDARP00000058628 | ENSDARP00000155344 | Actin alpha 1, skeletal muscle b. | Twinfilin actin-binding protein 1a. | 0.686 |
cap1 | acta1b | ENSDARP00000020578 | ENSDARP00000058628 | Adenylyl cyclase-associated protein; Belongs to the CAP family. | Actin alpha 1, skeletal muscle b. | 0.618 |
cap1 | capzb | ENSDARP00000020578 | ENSDARP00000140899 | Adenylyl cyclase-associated protein; Belongs to the CAP family. | F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. | 0.530 |
cap1 | twf1a | ENSDARP00000020578 | ENSDARP00000155344 | Adenylyl cyclase-associated protein; Belongs to the CAP family. | Twinfilin actin-binding protein 1a. | 0.637 |
cap2 | acta1b | ENSDARP00000139926 | ENSDARP00000058628 | Adenylyl cyclase-associated protein; Belongs to the CAP family. | Actin alpha 1, skeletal muscle b. | 0.670 |
cap2 | capzb | ENSDARP00000139926 | ENSDARP00000140899 | Adenylyl cyclase-associated protein; Belongs to the CAP family. | F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. | 0.733 |
cap2 | twf1a | ENSDARP00000139926 | ENSDARP00000155344 | Adenylyl cyclase-associated protein; Belongs to the CAP family. | Twinfilin actin-binding protein 1a. | 0.632 |
capzb | acta1b | ENSDARP00000140899 | ENSDARP00000058628 | F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. | Actin alpha 1, skeletal muscle b. | 0.894 |
capzb | cap1 | ENSDARP00000140899 | ENSDARP00000020578 | F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. | Adenylyl cyclase-associated protein; Belongs to the CAP family. | 0.530 |
capzb | cap2 | ENSDARP00000140899 | ENSDARP00000139926 | F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. | Adenylyl cyclase-associated protein; Belongs to the CAP family. | 0.733 |
capzb | twf1a | ENSDARP00000140899 | ENSDARP00000155344 | F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. | Twinfilin actin-binding protein 1a. | 0.871 |
clic5b | twf1a | ENSDARP00000029090 | ENSDARP00000155344 | Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. | Twinfilin actin-binding protein 1a. | 0.556 |
maea | MYO1D | ENSDARP00000070240 | ENSDARP00000067761 | E3 ubiquitin-protein transferase MAEA; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin- protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity). Plays a role in erythroblast maturati [...] | Unconventional myosin-Id; Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in the formation of Kupffer's vesicle, an organ that functions as left-right organizer during embryogenesis. Plays a role in vesicular trafficking events that are required for normal lumen expansion of Kupffer's vesicle. Required for normal orientation of cilia in Kupffer's vesicle, and thus for normal, unidirectional circular flow and normal angular flow velocity, which then mediates asymmetric gene expression and left-right asymmetric developm [...] | 0.515 |