STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
evx1Even-skipped homeobox 1. (377 aa)    
Predicted Functional Partners:
kcnk5b
Potassium channel, subfamily K, member 5b; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
   
  
 0.739
pax2a
Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation.
   
  
 0.626
isl1
Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity).
   
  
 0.625
lhx1a
LIM/homeobox protein Lhx1; Seems to play a role in dorsal axis formation.
   
  
 0.598
LHX3
LIM/homeobox protein Lhx3.
      
 0.595
olig2
Oligodendrocyte lineage transcription factor 2.
   
  
 0.566
hibadhb
3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.
      
 0.554
hibadha
3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.
      
 0.542
spryd3
SPRY domain-containing 3.
      
 0.526
gata3
Transcription factor GATA-3.
    
 
 0.512
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.