Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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Score
MW7_0806Protein involved in dihydrolipoyl dehydrogenase activity and gluconeogenesis. (461 aa)    
Predicted Functional Partners:
MW7_1865
Transketolase; Protein involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor and metabolic process.
 
 0.999
MW7_3491
2-oxoglutarate dehydrogenase e1 component; Protein involved in oxoglutarate dehydrogenase (succinyl-transferring) activity and glycolysis.
  
 0.977
odhB
Dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 0.977
aceF
Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 
 0.976
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
  
 0.969
aceE
Pyruvate dehydrogenase subunit E1; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 0.959
MW7_1862
Alpha/beta hydrolase; Protein involved in metabolic process.
 
 0.942
gcvH
Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 
 0.941
lpdA
Protein involved in dihydrolipoyl dehydrogenase activity and gluconeogenesis.
 
0.925
gcvT
Glycine cleavage complex protein T, aminomethyltransferase, tetrahydrofolate-dependent; The glycine cleavage system catalyzes the degradation of glycine.
 
 0.891
Your Current Organism:
Burkholderiaceae bacterium PBA
NCBI taxonomy Id: 795666
Other names: B. bacterium PBA
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