guaA protein (Burkholderiaceae bacterium PBA)

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guaA

GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (547 aa)

Predicted Functional Partners:

guaB

0.999

purL

0.982

apt

0.978

argS

0.974

pyrG

0.971

hisA

0.966

gmk

0.965

rplK

0.960

purA

0.959

gatB

0.955

Your Current Organism:

Burkholderiaceae bacterium PBA

NCBI taxonomy Id: 795666
Other names: B. bacterium PBA

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
apt	gmk	MW7_0372	MW7_0561	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.817
apt	guaA	MW7_0372	MW7_1925	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	0.978
apt	guaB	MW7_0372	MW7_1923	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Inosine-5 -monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.900
apt	hisA	MW7_0372	MW7_3299	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Protein involved in 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase activity and histidine biosynthetic process.	0.436
apt	purA	MW7_0372	MW7_3470	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.832
apt	purL	MW7_0372	MW7_1892	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.	0.885
apt	pyrG	MW7_0372	MW7_0422	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	PyrG protein; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.541
argS	gmk	MW7_0228	MW7_0561	Protein involved in arginine-tRNA ligase activity and arginyl-tRNA aminoacylation.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.523
argS	guaA	MW7_0228	MW7_1925	Protein involved in arginine-tRNA ligase activity and arginyl-tRNA aminoacylation.	GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	0.974
argS	purA	MW7_0228	MW7_3470	Protein involved in arginine-tRNA ligase activity and arginyl-tRNA aminoacylation.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.442
argS	purL	MW7_0228	MW7_1892	Protein involved in arginine-tRNA ligase activity and arginyl-tRNA aminoacylation.	Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.	0.773
argS	pyrG	MW7_0228	MW7_0422	Protein involved in arginine-tRNA ligase activity and arginyl-tRNA aminoacylation.	PyrG protein; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.882
argS	rplK	MW7_0228	MW7_0739	Protein involved in arginine-tRNA ligase activity and arginyl-tRNA aminoacylation.	50s ribosomal subunit protein l11 (methylation rna-binding); Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.	0.620
gatB	guaA	MW7_0080	MW7_1925	Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily.	GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	0.955
gatB	pyrG	MW7_0080	MW7_0422	Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily.	PyrG protein; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.655
gmk	apt	MW7_0561	MW7_0372	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	0.817
gmk	argS	MW7_0561	MW7_0228	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Protein involved in arginine-tRNA ligase activity and arginyl-tRNA aminoacylation.	0.523
gmk	guaA	MW7_0561	MW7_1925	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	0.965
gmk	guaB	MW7_0561	MW7_1923	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Inosine-5 -monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.901
gmk	purA	MW7_0561	MW7_3470	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.484