Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MW7_2425D-3-phosphoglycerate dehydrogenase; Protein involved in nucleotide binding and glycine metabolic process. (318 aa)    
Predicted Functional Partners:
serC
3-phosphoserine/phosphohydroxythreonine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
  
 0.838
MW7_1388
Protein involved in glyoxylate reductase activity and glyoxylate metabolic process; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
  
 
0.731
trpB
Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
  
 0.699
trpA
Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
   
 
  0.690
MW7_2108
Protein involved in hydroxypyruvate isomerase activity and pyruvate metabolic process; Belongs to the hyi family.
  
 
  0.689
ilvA
Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
   
 
 0.662
MW7_1865
Transketolase; Protein involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor and metabolic process.
   
 0.650
MW7_1683
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; Protein involved in catalytic activity and oxidation reduction; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
 
  
 
0.649
aceA
Protein involved in isocitrate lyase activity and glyoxylate cycle.
   
 
 0.649
MW7_2951
Helicase domain-containing protein; Protein involved in DNA binding and auxin biosynthetic process.
   
 0.639
Your Current Organism:
Burkholderiaceae bacterium PBA
NCBI taxonomy Id: 795666
Other names: B. bacterium PBA
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