STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MW7_2699DnaA regulatory inactivator Hda; Protein involved in negative regulation of DNA replication initiation; Belongs to the DnaA family. (239 aa)    
Predicted Functional Partners:
MW7_0006
Dna polymerase beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of repl [...]
  
 
 0.990
MW7_3245
Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily.
   
 
 0.886
MW7_2698
HAD-superfamily hydrolase; Protein involved in phosphoserine phosphatase activity and glycine metabolic process.
     0.817
MW7_2700
Hypothetical protein.
  
    0.800
rpmE2
LSU ribosomal protein L31P; Protein involved in structural constituent of ribosome and translation.
  
    0.775
dnaA
Chromosomal replication initiator protein DnaA, DNA-binding transcriptional dual regulator; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family.
  
 
0.753
pcnB
Poly polymerase; Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
 
   
 0.722
MW7_2694
Deoxynucleoside kinase; Protein involved in ATP binding and nucleobase, nucleoside, nucleotide and nucleic acid metabolic process.
     
 0.672
folK
7 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; Protein involved in 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity and folic acid biosynthetic process.
     
 0.672
MW7_2695
Hypothetical protein.
       0.659
Your Current Organism:
Burkholderiaceae bacterium PBA
NCBI taxonomy Id: 795666
Other names: B. bacterium PBA
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