node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADJ16082.1 | ADJ16097.1 | HacjB3_13505 | HacjB3_13580 | Repair helicase; COG0210 Superfamily I DNA and RNA helicases. | COG0178 Excinuclease ATPase subunit. | 0.795 |
ADJ16082.1 | dbh | HacjB3_13505 | HacjB3_09220 | Repair helicase; COG0210 Superfamily I DNA and RNA helicases. | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. | 0.519 |
ADJ16082.1 | dnaK | HacjB3_13505 | HacjB3_12500 | Repair helicase; COG0210 Superfamily I DNA and RNA helicases. | Molecular chaperone DnaK; Acts as a chaperone. | 0.542 |
ADJ16082.1 | fen | HacjB3_13505 | HacjB3_08280 | Repair helicase; COG0210 Superfamily I DNA and RNA helicases. | Flap endonuclease-1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] | 0.656 |
ADJ16082.1 | ligA | HacjB3_13505 | HacjB3_00855 | Repair helicase; COG0210 Superfamily I DNA and RNA helicases. | NAD-dependent DNA ligase LigA; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | 0.865 |
ADJ16082.1 | mutL | HacjB3_13505 | HacjB3_14385 | Repair helicase; COG0210 Superfamily I DNA and RNA helicases. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.876 |
ADJ16082.1 | radA | HacjB3_13505 | HacjB3_01350 | Repair helicase; COG0210 Superfamily I DNA and RNA helicases. | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.730 |
ADJ16082.1 | thrS | HacjB3_13505 | HacjB3_10945 | Repair helicase; COG0210 Superfamily I DNA and RNA helicases. | COG0441 Threonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.751 |
ADJ16082.1 | uvrB | HacjB3_13505 | HacjB3_00805 | Repair helicase; COG0210 Superfamily I DNA and RNA helicases. | Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.933 |
ADJ16082.1 | uvrC | HacjB3_13505 | HacjB3_00830 | Repair helicase; COG0210 Superfamily I DNA and RNA helicases. | Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.889 |
ADJ16097.1 | ADJ16082.1 | HacjB3_13580 | HacjB3_13505 | COG0178 Excinuclease ATPase subunit. | Repair helicase; COG0210 Superfamily I DNA and RNA helicases. | 0.795 |
ADJ16097.1 | dbh | HacjB3_13580 | HacjB3_09220 | COG0178 Excinuclease ATPase subunit. | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. | 0.517 |
ADJ16097.1 | dnaK | HacjB3_13580 | HacjB3_12500 | COG0178 Excinuclease ATPase subunit. | Molecular chaperone DnaK; Acts as a chaperone. | 0.505 |
ADJ16097.1 | fen | HacjB3_13580 | HacjB3_08280 | COG0178 Excinuclease ATPase subunit. | Flap endonuclease-1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] | 0.630 |
ADJ16097.1 | ligA | HacjB3_13580 | HacjB3_00855 | COG0178 Excinuclease ATPase subunit. | NAD-dependent DNA ligase LigA; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | 0.600 |
ADJ16097.1 | mutL | HacjB3_13580 | HacjB3_14385 | COG0178 Excinuclease ATPase subunit. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.646 |
ADJ16097.1 | radA | HacjB3_13580 | HacjB3_01350 | COG0178 Excinuclease ATPase subunit. | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.492 |
ADJ16097.1 | thrS | HacjB3_13580 | HacjB3_10945 | COG0178 Excinuclease ATPase subunit. | COG0441 Threonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.560 |
ADJ16097.1 | uvrB | HacjB3_13580 | HacjB3_00805 | COG0178 Excinuclease ATPase subunit. | Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.999 |
ADJ16097.1 | uvrC | HacjB3_13580 | HacjB3_00830 | COG0178 Excinuclease ATPase subunit. | Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.995 |