STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Sirt1Sirtuin 1. (696 aa)    
Predicted Functional Partners:
Trp53
Tumor protein p53.
    
 0.994
Foxo1
Forkhead box O1.
    
 0.988
Ccar2
Cell cycle and apoptosis regulator 2.
    
 0.979
Foxo3
Forkhead box O3.
    
 0.975
Pparg
Peroxisome proliferator activated receptor gamma.
    
 0.965
Ppargc1a
PPARG coactivator 1 alpha.
    
 0.963
Rela
RELA proto-oncogene, NF-kB subunit.
    
 0.960
Sirt7
Sirtuin 7.
  
0.957
Sirt6
Sirtuin 6.
  
0.953
Foxo4
Forkhead box O4.
    
 0.947
Your Current Organism:
Microtus ochrogaster
NCBI taxonomy Id: 79684
Other names: M. ochrogaster, prairie vole, prairie voles
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.