A0A137NQ20 protein (Conidiobolus coronatus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

Coexpression

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[Homology]

Score

A0A137NQ20

Uncharacterized protein. (446 aa)

Predicted Functional Partners:

A0A137NVX8

0.983

A0A137PG18

0.974

A0A137P2M8

0.972

A0A137PB66

0.957

A0A137PC67

0.952

A0A137NV51

0.943

NOP7

0.910

A0A137PEI3

0.910

A0A137PIP1

0.906

A0A137PCR7

0.905

Your Current Organism:

Conidiobolus coronatus

NCBI taxonomy Id: 796925
Other names: C. coronatus NRRL 28638, Conidiobolus coronatus NRRL 28638

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A137NQ20	A0A137NV51	A0A137NQ20	A0A137NV51	Uncharacterized protein.	Brix-domain-containing protein.	0.943
A0A137NQ20	A0A137NVX8	A0A137NQ20	A0A137NVX8	Uncharacterized protein.	Brix-domain-containing protein.	0.983
A0A137NQ20	A0A137P2M8	A0A137NQ20	A0A137P2M8	Uncharacterized protein.	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.	0.972
A0A137NQ20	A0A137PB66	A0A137NQ20	A0A137PB66	Uncharacterized protein.	Brix-domain-containing protein.	0.957
A0A137NQ20	A0A137PC67	A0A137NQ20	A0A137PC67	Uncharacterized protein.	Rrp15p-domain-containing protein.	0.952
A0A137NQ20	A0A137PCR7	A0A137NQ20	A0A137PCR7	Uncharacterized protein.	NUC153 domain-containing protein.	0.905
A0A137NQ20	A0A137PEI3	A0A137NQ20	A0A137PEI3	Uncharacterized protein.	Ribosomal protein L1.	0.910
A0A137NQ20	A0A137PG18	A0A137NQ20	A0A137PG18	Uncharacterized protein.	Protein MAK16; Belongs to the MAK16 family.	0.974
A0A137NQ20	A0A137PIP1	A0A137NQ20	A0A137PIP1	Uncharacterized protein.	Ribosome biogenesis protein RLP24.	0.906
A0A137NQ20	NOP7	A0A137NQ20	A0A137NWZ5	Uncharacterized protein.	Pescadillo homolog; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.910
A0A137NV51	A0A137NQ20	A0A137NV51	A0A137NQ20	Brix-domain-containing protein.	Uncharacterized protein.	0.943
A0A137NV51	A0A137NVX8	A0A137NV51	A0A137NVX8	Brix-domain-containing protein.	Brix-domain-containing protein.	0.922
A0A137NV51	A0A137P2M8	A0A137NV51	A0A137P2M8	Brix-domain-containing protein.	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.	0.995
A0A137NV51	A0A137PB66	A0A137NV51	A0A137PB66	Brix-domain-containing protein.	Brix-domain-containing protein.	0.994
A0A137NV51	A0A137PC67	A0A137NV51	A0A137PC67	Brix-domain-containing protein.	Rrp15p-domain-containing protein.	0.976
A0A137NV51	A0A137PCR7	A0A137NV51	A0A137PCR7	Brix-domain-containing protein.	NUC153 domain-containing protein.	0.852
A0A137NV51	A0A137PEI3	A0A137NV51	A0A137PEI3	Brix-domain-containing protein.	Ribosomal protein L1.	0.993
A0A137NV51	A0A137PG18	A0A137NV51	A0A137PG18	Brix-domain-containing protein.	Protein MAK16; Belongs to the MAK16 family.	0.987
A0A137NV51	A0A137PIP1	A0A137NV51	A0A137PIP1	Brix-domain-containing protein.	Ribosome biogenesis protein RLP24.	0.990
A0A137NV51	NOP7	A0A137NV51	A0A137NWZ5	Brix-domain-containing protein.	Pescadillo homolog; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.984

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Network Stats

number of nodes:

7

number of edges:

9

average node degree:

2.57

avg. local clustering coefficient:

0.838

expected number of edges:

7

PPI enrichment p-value:

0.28

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0002181

Cytoplasmic translation

6 of 39

2.28

4.4

7.37e-10

GO:0006412

Translation

9 of 233

1.68

3.32

7.32e-11

GO:0042273

Ribosomal large subunit biogenesis

5 of 55

2.05

2.97

5.01e-07

GO:0000027

Ribosomal large subunit assembly

2 of 15

2.21

0.83

0.0295

GO:0044237

Cellular metabolic process

10 of 4140

0.47

0.33

0.0224

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

9 of 115

1.98

5.12

4.52e-14

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0022625

Cytosolic large ribosomal subunit

9 of 39

2.45

8.14

2.79e-18

GO:0032991

Protein-containing complex

10 of 3096

0.6

0.49

0.00056

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:161

Cytosolic large ribosomal subunit

8 of 33

2.47

7.45

2.18e-16

CL:155

GTP hydrolysis and joining of the 60S ribosomal subunit

9 of 60

2.26

6.88

1.64e-16

CL:118

SRP-dependent cotranslational protein targeting to membrane, and Voltage gated Potassium channels

10 of 122

2.0

5.82

1.64e-16

CL:162

Cytosolic large ribosomal subunit

6 of 24

2.49

5.6

5.74e-12

CL:163

Cytosolic large ribosomal subunit

4 of 19

2.41

3.33

3.48e-07

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

egz03010

Ribosome

9 of 81

2.13

6.39

1.57e-16

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72706

GTP hydrolysis and joining of the 60S ribosomal subunit

9 of 68

2.21

6.58

3.45e-16

MAP-975956

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

9 of 78

2.15

6.29

5.48e-16

MAP-1799339

SRP-dependent cotranslational protein targeting to membrane

9 of 83

2.12

6.17

6.19e-16

MAP-72737

Cap-dependent Translation Initiation

9 of 93

2.07

5.89

1.22e-15

MAP-72613

Eukaryotic Translation Initiation

9 of 93

2.07

5.89

1.22e-15

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0022626

Cytosolic ribosome

7 of 37

2.37

5.72

1.04e-12

GOCC:0022625

Cytosolic large ribosomal subunit

5 of 13

2.67

4.89

4.74e-10

GOCC:0015934

Large ribosomal subunit

6 of 50

2.17

4.27

5.92e-10

GOCC:0042788

Polysomal ribosome

4 of 15

2.51

3.53

1.77e-07

GOCC:1990904

Ribonucleoprotein complex

8 of 302

1.51

2.56

2.96e-09

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

9 of 70

2.2

6.73

7.94e-17

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Enrichment analysis is still ongoing, please wait ...

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