A0A137NQK2 protein (Conidiobolus coronatus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

A0A137NQK2

Uncharacterized protein. (754 aa)

Predicted Functional Partners:

A0A137NVT2

0.609

A0A137P4R0

0.539

A0A137P865

0.538

A0A137PG72

0.538

A0A137P185

0.534

A0A137PF14

0.528

A0A137NVZ6

0.522

A0A137P3P2

0.519

A0A137PCV3

0.519

A0A137P2S6

0.518

Your Current Organism:

Conidiobolus coronatus

NCBI taxonomy Id: 796925
Other names: C. coronatus NRRL 28638, Conidiobolus coronatus NRRL 28638

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A137NQK2	A0A137NVT2	Uncharacterized protein.	Urea carboxylase.	0.609
A0A137NQK2	A0A137NVZ6	Uncharacterized protein.	TPR-like protein.	0.522
A0A137NQK2	A0A137P185	Uncharacterized protein.	Uncharacterized protein.	0.534
A0A137NQK2	A0A137P2S6	Uncharacterized protein.	Uncharacterized protein.	0.518
A0A137NQK2	A0A137P3P2	Uncharacterized protein.	14-3-3 protein; Belongs to the 14-3-3 family.	0.519
A0A137NQK2	A0A137P4R0	Uncharacterized protein.	Cytosolic glyco protein FP21; Belongs to the SKP1 family.	0.539
A0A137NQK2	A0A137P865	Uncharacterized protein.	Uncharacterized protein.	0.538
A0A137NQK2	A0A137PCV3	Uncharacterized protein.	14-3-3 protein; Belongs to the 14-3-3 family.	0.519
A0A137NQK2	A0A137PF14	Uncharacterized protein.	WD40 repeat-like protein.	0.528
A0A137NQK2	A0A137PG72	Uncharacterized protein.	Uncharacterized protein.	0.538
A0A137NVT2	A0A137NQK2	Urea carboxylase.	Uncharacterized protein.	0.609
A0A137NVZ6	A0A137NQK2	TPR-like protein.	Uncharacterized protein.	0.522
A0A137NVZ6	A0A137P2S6	TPR-like protein.	Uncharacterized protein.	0.999
A0A137P185	A0A137NQK2	Uncharacterized protein.	Uncharacterized protein.	0.534
A0A137P185	A0A137P3P2	Uncharacterized protein.	14-3-3 protein; Belongs to the 14-3-3 family.	0.721
A0A137P185	A0A137P4R0	Uncharacterized protein.	Cytosolic glyco protein FP21; Belongs to the SKP1 family.	0.655
A0A137P185	A0A137PCV3	Uncharacterized protein.	14-3-3 protein; Belongs to the 14-3-3 family.	0.721
A0A137P185	A0A137PF14	Uncharacterized protein.	WD40 repeat-like protein.	0.854
A0A137P2S6	A0A137NQK2	Uncharacterized protein.	Uncharacterized protein.	0.518
A0A137P2S6	A0A137NVZ6	Uncharacterized protein.	TPR-like protein.	0.999

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

12

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009168

Purine ribonucleoside monophosphate biosynthetic process

10 of 16

2.96

12.45

5.84e-25

GO:0006189

De novo IMP biosynthetic process

8 of 8

3.17

10.77

6.83e-21

GO:0009152

Purine ribonucleotide biosynthetic process

10 of 75

2.29

8.19

3.43e-20

GO:0006144

Purine nucleobase metabolic process

5 of 19

2.59

5.02

1.82e-10

GO:0009113

Purine nucleobase biosynthetic process

4 of 9

2.81

4.39

6.59e-09

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016879

Ligase activity, forming carbon-nitrogen bonds

4 of 57

2.01

2.0

9.05e-05

GO:0016742

Hydroxymethyl-, formyl- and related transferase activity

2 of 7

2.62

1.24

0.0054

GO:0016763

Pentosyltransferase activity

2 of 23

2.11

0.96

0.0159

GO:0046872

Metal ion binding

7 of 1500

0.84

0.61

0.0054

GO:0032555

Purine ribonucleotide binding

6 of 1223

0.86

0.56

0.0138

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 4945

0.51

0.41

0.0018

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:12556

De novo IMP biosynthetic process

10 of 10

3.17

13.83

5.88e-27

CL:12554

Purine nucleoside monophosphate metabolic process, and Purine-containing compound catabolic process

11 of 27

2.78

12.84

4.74e-27

CL:12559

De novo IMP biosynthetic process

5 of 5

3.17

6.34

2.23e-12

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00230

Purine metabolism

10 of 118

2.1

6.81

1.07e-18

map00250

Alanine, aspartate and glutamate metabolism

3 of 44

2.0

1.91

0.00014

map01110

Biosynthesis of secondary metabolites

8 of 615

1.28

1.81

5.03e-08

map00670

One carbon pool by folate

2 of 24

2.09

1.26

0.0039

map01100

Metabolic pathways

10 of 2204

0.82

0.85

1.06e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-73817

Purine ribonucleoside monophosphate biosynthesis

9 of 12

3.04

11.59

7.36e-23

MAP-8956320

Nucleotide biosynthesis

9 of 18

2.87

10.82

5.87e-22

MAP-15869

Metabolism of nucleotides

10 of 67

2.34

8.57

1.13e-20

MAP-1430728

Metabolism

10 of 1495

0.99

1.17

1.13e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0658

Purine biosynthesis

3 of 5

2.95

3.0

3.22e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02769

AIR synthase related protein, C-terminal domain

2 of 2

3.17

1.41

0.0029

PF00156

Phosphoribosyl transferase domain

2 of 4

2.87

1.34

0.0037

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036921

PurM-like, N-terminal domain superfamily

2 of 2

3.17

1.15

0.0085

IPR036676

PurM-like, C-terminal domain superfamily

2 of 2

3.17

1.15

0.0085

IPR010918

PurM-like, C-terminal domain

2 of 2

3.17

1.15

0.0085

IPR013815

ATP-grasp fold, subdomain 1

2 of 9

2.51

0.94

0.0194

IPR011054

Rudiment single hybrid motif

2 of 9

2.51

0.94

0.0194

(more ...)

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