STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tgtQueuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (373 aa)    
Predicted Functional Partners:
queA
S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
 
 0.998
secF
Protein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily.
  
    0.793
guaA
GMP synthase (glutamine-hydrolyzing) domain-containing protein; Catalyzes the synthesis of GMP from XMP.
   
  
 0.792
EHL17856.1
Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
  
  
 0.657
ruvB
Holliday junction ATP-dependent DNA helicase ruvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
  
    0.642
EHL17055.1
Preprotein translocase, YajC subunit.
  
    0.623
EHL14679.1
Hypothetical protein.
       0.608
recO
DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination.
       0.608
EHL14683.1
SpoIID/LytB domain-containing protein.
       0.588
EHL18344.1
Rod shape-determining protein MreC; Involved in formation and maintenance of cell shape.
  
    0.541
Your Current Organism:
Peptoanaerobacter stomatis
NCBI taxonomy Id: 796937
Other names: ATCC BAA-2665, DSM 28705, HM-483, P. stomatis, Peptoanaerobacter stomatis Sizova et al. 2016, Peptostreptococcaceae bacterium ACC19a, Peptostreptococcaceae bacterium CM2, Peptostreptococcaceae bacterium CM5, Peptostreptococcaceae bacterium OBRC8, strain ACC19a
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.