STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C475_09234COG0720 6-pyruvoyl-tetrahydropterin synthase. (149 aa)    
Predicted Functional Partners:
queE
Radical SAM domain-containing protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
 
 
 0.992
queC
exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.
 
  
 0.972
mptE
Hypothetical protein; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family.
    
 0.710
mptA
GTP cyclohydrolase; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
 
  
 0.691
C475_08706
COG0720 6-pyruvoyl-tetrahydropterin synthase.
     
 0.674
C475_11415
Hypothetical protein.
    
 0.564
cysS
COG0215 Cysteinyl-tRNA synthetase.
   
  
 0.494
C475_12932
Hypothetical protein; COG0526 Thiol-disulfide isomerase and thioredoxins.
  
     0.440
C475_09239
Fjo21; COG4270 Predicted membrane protein.
       0.400
Your Current Organism:
Halosimplex carlsbadense
NCBI taxonomy Id: 797114
Other names: H. carlsbadense 2-9-1, Halosimplex carlsbadense 2-9-1, Halosimplex carlsbadense ATCC BAA-75, Halosimplex carlsbadense JCM 11222, Halosimplex carlsbadense str. 2-9-1, Halosimplex carlsbadense strain 2-9-1
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