STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (510 aa)    
Predicted Functional Partners:
pan
Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...]
   
 0.999
C475_18418
Proteasome Rpn11 subunit JAMM motif protein; COG1310 Predicted metal-dependent protease of the PAD1/JAB1 superfamily.
   
 0.999
C475_13407
COG0578 Glycerol-3-phosphate dehydrogenase.
 
 0.995
C475_11595
COG0578 Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
 
 
 0.987
rpl40e
COG1552 Ribosomal protein L40E; Belongs to the eukaryotic ribosomal protein eL40 family.
    
 0.961
C475_10213
Proteasome endopeptidase complex; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family.
   
 0.934
C475_10218
Proteasome subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family.
   
 0.934
psmB
Proteasome subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
   
 0.934
psmA
Proteasome subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
   
 0.934
psmA-2
Proteasome subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
   
 0.934
Your Current Organism:
Halosimplex carlsbadense
NCBI taxonomy Id: 797114
Other names: H. carlsbadense 2-9-1, Halosimplex carlsbadense 2-9-1, Halosimplex carlsbadense ATCC BAA-75, Halosimplex carlsbadense JCM 11222, Halosimplex carlsbadense str. 2-9-1, Halosimplex carlsbadense strain 2-9-1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.