| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEH36052.1 | AEH36143.1 | Halxa_1419 | Halxa_1511 | Cell division control protein 6-like protein; Involved in regulation of DNA replication. | PFAM: Phosphoesterase, RecJ-like; Phosphoesterase, DHHA1; KEGG: htu:Htur_3679 phosphoesterase RecJ domain protein. | 0.629 |
| AEH36052.1 | dnaG | Halxa_1419 | Halxa_2115 | Cell division control protein 6-like protein; Involved in regulation of DNA replication. | UPF0095 protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | 0.827 |
| AEH36052.1 | endA | Halxa_1419 | Halxa_1143 | Cell division control protein 6-like protein; Involved in regulation of DNA replication. | tRNA-splicing endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. | 0.656 |
| AEH36052.1 | fen | Halxa_1419 | Halxa_3724 | Cell division control protein 6-like protein; Involved in regulation of DNA replication. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.680 |
| AEH36052.1 | polB | Halxa_1419 | Halxa_1422 | Cell division control protein 6-like protein; Involved in regulation of DNA replication. | DNA-directed DNA polymerase; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | 0.911 |
| AEH36052.1 | priS | Halxa_1419 | Halxa_0760 | Cell division control protein 6-like protein; Involved in regulation of DNA replication. | DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] | 0.875 |
| AEH36052.1 | spt5 | Halxa_1419 | Halxa_4114 | Cell division control protein 6-like protein; Involved in regulation of DNA replication. | NusG antitermination factor; Stimulates transcription elongation; Belongs to the archaeal Spt5 family. | 0.633 |
| AEH36143.1 | AEH36052.1 | Halxa_1511 | Halxa_1419 | PFAM: Phosphoesterase, RecJ-like; Phosphoesterase, DHHA1; KEGG: htu:Htur_3679 phosphoesterase RecJ domain protein. | Cell division control protein 6-like protein; Involved in regulation of DNA replication. | 0.629 |
| AEH36143.1 | AEH36720.1 | Halxa_1511 | Halxa_2095 | PFAM: Phosphoesterase, RecJ-like; Phosphoesterase, DHHA1; KEGG: htu:Htur_3679 phosphoesterase RecJ domain protein. | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family. | 0.891 |
| AEH36143.1 | dnaG | Halxa_1511 | Halxa_2115 | PFAM: Phosphoesterase, RecJ-like; Phosphoesterase, DHHA1; KEGG: htu:Htur_3679 phosphoesterase RecJ domain protein. | UPF0095 protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | 0.842 |
| AEH36143.1 | endA | Halxa_1511 | Halxa_1143 | PFAM: Phosphoesterase, RecJ-like; Phosphoesterase, DHHA1; KEGG: htu:Htur_3679 phosphoesterase RecJ domain protein. | tRNA-splicing endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. | 0.619 |
| AEH36143.1 | fen | Halxa_1511 | Halxa_3724 | PFAM: Phosphoesterase, RecJ-like; Phosphoesterase, DHHA1; KEGG: htu:Htur_3679 phosphoesterase RecJ domain protein. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.625 |
| AEH36143.1 | polB | Halxa_1511 | Halxa_1422 | PFAM: Phosphoesterase, RecJ-like; Phosphoesterase, DHHA1; KEGG: htu:Htur_3679 phosphoesterase RecJ domain protein. | DNA-directed DNA polymerase; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | 0.934 |
| AEH36143.1 | priS | Halxa_1511 | Halxa_0760 | PFAM: Phosphoesterase, RecJ-like; Phosphoesterase, DHHA1; KEGG: htu:Htur_3679 phosphoesterase RecJ domain protein. | DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] | 0.743 |
| AEH36143.1 | spt5 | Halxa_1511 | Halxa_4114 | PFAM: Phosphoesterase, RecJ-like; Phosphoesterase, DHHA1; KEGG: htu:Htur_3679 phosphoesterase RecJ domain protein. | NusG antitermination factor; Stimulates transcription elongation; Belongs to the archaeal Spt5 family. | 0.678 |
| AEH36720.1 | AEH36143.1 | Halxa_2095 | Halxa_1511 | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family. | PFAM: Phosphoesterase, RecJ-like; Phosphoesterase, DHHA1; KEGG: htu:Htur_3679 phosphoesterase RecJ domain protein. | 0.891 |
| AEH36720.1 | dnaG | Halxa_2095 | Halxa_2115 | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family. | UPF0095 protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | 0.813 |
| AEH36720.1 | fen | Halxa_2095 | Halxa_3724 | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.742 |
| AEH36720.1 | gltX | Halxa_2095 | Halxa_0725 | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family. | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). | 0.773 |
| AEH36720.1 | spt5 | Halxa_2095 | Halxa_4114 | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family. | NusG antitermination factor; Stimulates transcription elongation; Belongs to the archaeal Spt5 family. | 0.661 |
