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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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folDBifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (297 aa)    
Predicted Functional Partners:
AEH38259.1
Phosphoribosylglycinamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, formylation region; TIGRFAM: Phosphoribosylglycinamide formyltransferase; KEGG: htu:Htur_0785 phosphoribosylglycinamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme, formylation region; Formyl transferase, N-terminal.
 
 0.990
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
 
 0.978
glyA-2
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
 
 0.978
AEH36031.1
KEGG: hvo:HVO_B0014 sacrosine dehydrogenase/glycine cleavage T-protein; PFAM: FAD dependent oxidoreductase; Glycine cleavage T-protein, N-terminal; Glycine cleavage T-protein, C-terminal barrel.
  
 0.969
AEH35416.1
PFAM: Aminotransferase, class V/Cysteine desulfurase; KEGG: htu:Htur_2314 glycine dehydrogenase (decarboxylating).
  
 
 0.960
AEH38245.1
PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: hsl:OE3566F 5-formyltetrahydrofolate cyclo-ligase.
   
 0.960
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
  
 
 0.957
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.948
AEH36332.1
Formyltetrahydrofolate deformylase; KEGG: htu:Htur_0654 formyl transferase domain protein; PFAM: Formyl transferase, N-terminal; Amino acid-binding ACT.
  
  
 0.941
gcvT
Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.
  
 0.938
Your Current Organism:
Halopiger xanaduensis
NCBI taxonomy Id: 797210
Other names: H. xanaduensis SH-6, Halopiger xanaduensis JCM 14033, Halopiger xanaduensis SH-6, Halopiger xanaduensis str. SH-6, Halopiger xanaduensis strain SH-6
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