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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHF99402.1Isochorismate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (445 aa)    
Predicted Functional Partners:
menD
2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
 
 0.998
AHF98710.1
Anthranilate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
  0.925
AHF99836.1
Para-aminobenzoate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
  0.924
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
  
 0.899
aroE
Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
 
  
 0.889
AHF98709.1
Anthranilate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
0.877
trpE
Anthranilate synthase; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.
 
  
0.872
AHF99002.1
Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.808
AHF99519.1
Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.808
AHF99783.1
Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.808
Your Current Organism:
Halostagnicola larsenii
NCBI taxonomy Id: 797299
Other names: H. larsenii XH-48, Halostagnicola larsenii JCM 13463, Halostagnicola larsenii XH-48, Halostagnicola larsenii str. XH-48, Halostagnicola larsenii strain XH-48
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