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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pan26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] (430 aa)    
Predicted Functional Partners:
AGB15438.1
Putative metal-dependent protease of the PAD1/JAB1 superfamily.
  
 0.948
pan-2
26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...]
  
  
 
0.902
psmA
Proteasome endopeptidase complex, archaeal, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
 0.894
AGB17624.1
Ribosomal protein L40E; Belongs to the eukaryotic ribosomal protein eL40 family.
  
  0.869
AGB16746.1
20S proteasome subunit (alpha or beta); Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family.
 
 0.856
AGB16747.1
20S proteasome subunit (alpha or beta); Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
 0.830
psmB
Proteasome endopeptidase complex, archaeal, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
  
 0.805
AGB14728.1
Trypsin-like serine protease with C-terminal PDZ domain; PFAM: Trypsin.
   
 0.758
AGB17574.1
Trypsin-like serine protease with C-terminal PDZ domain; PFAM: Trypsin.
   
 0.758
AGB14805.1
TPR repeat-containing protein; PFAM: Tetratricopeptide repeat.
  
  0.744
Your Current Organism:
Halovivax ruber
NCBI taxonomy Id: 797302
Other names: H. ruber XH-70, Halovivax ruber JCM 13892, Halovivax ruber XH-70, Halovivax ruber str. XH-70, Halovivax ruber strain XH-70
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.