| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGB14734.1 | AGB14857.1 | Halru_0082 | Halru_0211 | Ribonuclease H, mammalian HI/archaeal HII subfamily; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication. | 0.655 |
| AGB14734.1 | AGB15555.1 | Halru_0082 | Halru_0935 | Ribonuclease H, mammalian HI/archaeal HII subfamily; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | Hypothetical protein. | 0.628 |
| AGB14734.1 | AGB15795.1 | Halru_0082 | Halru_1178 | Ribonuclease H, mammalian HI/archaeal HII subfamily; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | DNA polymerase elongation subunit (family B); PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain. | 0.562 |
| AGB14734.1 | AGB17681.1 | Halru_0082 | Halru_3115 | Ribonuclease H, mammalian HI/archaeal HII subfamily; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | Putative ATPase involved in replication control, Cdc46/Mcm family; PFAM: MCM2/3/5 family; Belongs to the MCM family. | 0.646 |
| AGB14734.1 | fen | Halru_0082 | Halru_0771 | Ribonuclease H, mammalian HI/archaeal HII subfamily; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.612 |
| AGB14734.1 | pcn | Halru_0082 | Halru_0352 | Ribonuclease H, mammalian HI/archaeal HII subfamily; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | DNA polymerase sliding clamp subunit; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.823 |
| AGB14734.1 | pcn-2 | Halru_0082 | Halru_2878 | Ribonuclease H, mammalian HI/archaeal HII subfamily; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | DNA polymerase sliding clamp subunit; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.886 |
| AGB14734.1 | priL | Halru_0082 | Halru_0235 | Ribonuclease H, mammalian HI/archaeal HII subfamily; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | DNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.747 |
| AGB14734.1 | priS | Halru_0082 | Halru_1764 | Ribonuclease H, mammalian HI/archaeal HII subfamily; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | DNA primase, eukaryotic-type, small subunit, putative; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extens [...] | 0.810 |
| AGB14734.1 | radA | Halru_0082 | Halru_2758 | Ribonuclease H, mammalian HI/archaeal HII subfamily; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.556 |
| AGB14857.1 | AGB14734.1 | Halru_0211 | Halru_0082 | Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication. | Ribonuclease H, mammalian HI/archaeal HII subfamily; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.655 |
| AGB14857.1 | AGB15555.1 | Halru_0211 | Halru_0935 | Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication. | Hypothetical protein. | 0.902 |
| AGB14857.1 | AGB15795.1 | Halru_0211 | Halru_1178 | Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication. | DNA polymerase elongation subunit (family B); PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain. | 0.653 |
| AGB14857.1 | AGB17681.1 | Halru_0211 | Halru_3115 | Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication. | Putative ATPase involved in replication control, Cdc46/Mcm family; PFAM: MCM2/3/5 family; Belongs to the MCM family. | 0.929 |
| AGB14857.1 | fen | Halru_0211 | Halru_0771 | Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.594 |
| AGB14857.1 | pcn | Halru_0211 | Halru_0352 | Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication. | DNA polymerase sliding clamp subunit; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.692 |
| AGB14857.1 | pcn-2 | Halru_0211 | Halru_2878 | Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication. | DNA polymerase sliding clamp subunit; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.681 |
| AGB14857.1 | priL | Halru_0211 | Halru_0235 | Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication. | DNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.891 |
| AGB14857.1 | priS | Halru_0211 | Halru_1764 | Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication. | DNA primase, eukaryotic-type, small subunit, putative; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extens [...] | 0.818 |
| AGB14857.1 | radA | Halru_0211 | Halru_2758 | Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication. | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.595 |
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