| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGB14823.1 | nadK | Halru_0171 | Halru_1146 | Dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase. | Putative sugar kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.678 |
| AGB15405.1 | AGB16879.1 | Halru_0779 | Halru_2294 | Putative sugar kinase; PFAM: ATP-NAD kinase. | PFAM: Cytidylyltransferase; TIGRFAM: nicotinamide-nucleotide adenylyltransferase; cytidyltransferase-related domain. | 0.914 |
| AGB15405.1 | mptA | Halru_0779 | Halru_1192 | Putative sugar kinase; PFAM: ATP-NAD kinase. | TIGR00294 family protein; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. | 0.413 |
| AGB15405.1 | nadE | Halru_0779 | Halru_0521 | Putative sugar kinase; PFAM: ATP-NAD kinase. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.920 |
| AGB15405.1 | nadK | Halru_0779 | Halru_1146 | Putative sugar kinase; PFAM: ATP-NAD kinase. | Putative sugar kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.928 |
| AGB15764.1 | nadK | Halru_1147 | Halru_1146 | PFAM: KaiC; TIGRFAM: KaiC domain protein, AF_0351 family. | Putative sugar kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.887 |
| AGB15826.1 | dacZ | Halru_1211 | Halru_2167 | Diphthine-ammonia ligase; PFAM: ATP-binding region; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | Hypothetical protein; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. | 0.531 |
| AGB15826.1 | hisC | Halru_1211 | Halru_1697 | Diphthine-ammonia ligase; PFAM: ATP-binding region; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase. | 0.494 |
| AGB15826.1 | mptA | Halru_1211 | Halru_1192 | Diphthine-ammonia ligase; PFAM: ATP-binding region; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | TIGR00294 family protein; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. | 0.521 |
| AGB15826.1 | nadK | Halru_1211 | Halru_1146 | Diphthine-ammonia ligase; PFAM: ATP-binding region; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | Putative sugar kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.520 |
| AGB16879.1 | AGB15405.1 | Halru_2294 | Halru_0779 | PFAM: Cytidylyltransferase; TIGRFAM: nicotinamide-nucleotide adenylyltransferase; cytidyltransferase-related domain. | Putative sugar kinase; PFAM: ATP-NAD kinase. | 0.914 |
| AGB16879.1 | nadE | Halru_2294 | Halru_0521 | PFAM: Cytidylyltransferase; TIGRFAM: nicotinamide-nucleotide adenylyltransferase; cytidyltransferase-related domain. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.957 |
| AGB16879.1 | nadK | Halru_2294 | Halru_1146 | PFAM: Cytidylyltransferase; TIGRFAM: nicotinamide-nucleotide adenylyltransferase; cytidyltransferase-related domain. | Putative sugar kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.914 |
| AGB17493.1 | nadK | Halru_2923 | Halru_1146 | Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase component; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | Putative sugar kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.562 |
| dacZ | AGB15826.1 | Halru_2167 | Halru_1211 | Hypothetical protein; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. | Diphthine-ammonia ligase; PFAM: ATP-binding region; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | 0.531 |
| dacZ | hisC | Halru_2167 | Halru_1697 | Hypothetical protein; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. | PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase. | 0.570 |
| dacZ | mptA | Halru_2167 | Halru_1192 | Hypothetical protein; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. | TIGR00294 family protein; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. | 0.515 |
| dacZ | nadK | Halru_2167 | Halru_1146 | Hypothetical protein; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. | Putative sugar kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.543 |
| hisC | AGB15826.1 | Halru_1697 | Halru_1211 | PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase. | Diphthine-ammonia ligase; PFAM: ATP-binding region; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | 0.494 |
| hisC | dacZ | Halru_1697 | Halru_2167 | PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase. | Hypothetical protein; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. | 0.570 |
