| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGB16063.1 | AGB16064.1 | Halru_1453 | Halru_1454 | Helicase family protein with metal-binding cysteine cluster; PFAM: Helicase conserved C-terminal domain; Domain of unknown function (DUF1998); DEAD/DEAH box helicase. | Hypothetical protein; TIGRFAM: RecB family nuclease, putative, TM0106 family. | 0.903 |
| AGB16063.1 | AGB16066.1 | Halru_1453 | Halru_1456 | Helicase family protein with metal-binding cysteine cluster; PFAM: Helicase conserved C-terminal domain; Domain of unknown function (DUF1998); DEAD/DEAH box helicase. | PFAM: Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | 0.498 |
| AGB16063.1 | purD | Halru_1453 | Halru_1452 | Helicase family protein with metal-binding cysteine cluster; PFAM: Helicase conserved C-terminal domain; Domain of unknown function (DUF1998); DEAD/DEAH box helicase. | Phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C domain; TIGRFAM: phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.525 |
| AGB16063.1 | thyA | Halru_1453 | Halru_1455 | Helicase family protein with metal-binding cysteine cluster; PFAM: Helicase conserved C-terminal domain; Domain of unknown function (DUF1998); DEAD/DEAH box helicase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.498 |
| AGB16064.1 | AGB16063.1 | Halru_1454 | Halru_1453 | Hypothetical protein; TIGRFAM: RecB family nuclease, putative, TM0106 family. | Helicase family protein with metal-binding cysteine cluster; PFAM: Helicase conserved C-terminal domain; Domain of unknown function (DUF1998); DEAD/DEAH box helicase. | 0.903 |
| AGB16064.1 | AGB16066.1 | Halru_1454 | Halru_1456 | Hypothetical protein; TIGRFAM: RecB family nuclease, putative, TM0106 family. | PFAM: Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | 0.501 |
| AGB16064.1 | purD | Halru_1454 | Halru_1452 | Hypothetical protein; TIGRFAM: RecB family nuclease, putative, TM0106 family. | Phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C domain; TIGRFAM: phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.523 |
| AGB16064.1 | thyA | Halru_1454 | Halru_1455 | Hypothetical protein; TIGRFAM: RecB family nuclease, putative, TM0106 family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.501 |
| AGB16066.1 | AGB16063.1 | Halru_1456 | Halru_1453 | PFAM: Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Helicase family protein with metal-binding cysteine cluster; PFAM: Helicase conserved C-terminal domain; Domain of unknown function (DUF1998); DEAD/DEAH box helicase. | 0.498 |
| AGB16066.1 | AGB16064.1 | Halru_1456 | Halru_1454 | PFAM: Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Hypothetical protein; TIGRFAM: RecB family nuclease, putative, TM0106 family. | 0.501 |
| AGB16066.1 | purD | Halru_1456 | Halru_1452 | PFAM: Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C domain; TIGRFAM: phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.600 |
| AGB16066.1 | thyA | Halru_1456 | Halru_1455 | PFAM: Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
| purD | AGB16063.1 | Halru_1452 | Halru_1453 | Phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C domain; TIGRFAM: phosphoribosylamine--glycine ligase; Belongs to the GARS family. | Helicase family protein with metal-binding cysteine cluster; PFAM: Helicase conserved C-terminal domain; Domain of unknown function (DUF1998); DEAD/DEAH box helicase. | 0.525 |
| purD | AGB16064.1 | Halru_1452 | Halru_1454 | Phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C domain; TIGRFAM: phosphoribosylamine--glycine ligase; Belongs to the GARS family. | Hypothetical protein; TIGRFAM: RecB family nuclease, putative, TM0106 family. | 0.523 |
| purD | AGB16066.1 | Halru_1452 | Halru_1456 | Phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C domain; TIGRFAM: phosphoribosylamine--glycine ligase; Belongs to the GARS family. | PFAM: Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | 0.600 |
| purD | thyA | Halru_1452 | Halru_1455 | Phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C domain; TIGRFAM: phosphoribosylamine--glycine ligase; Belongs to the GARS family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.556 |
| thyA | AGB16063.1 | Halru_1455 | Halru_1453 | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | Helicase family protein with metal-binding cysteine cluster; PFAM: Helicase conserved C-terminal domain; Domain of unknown function (DUF1998); DEAD/DEAH box helicase. | 0.498 |
| thyA | AGB16064.1 | Halru_1455 | Halru_1454 | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | Hypothetical protein; TIGRFAM: RecB family nuclease, putative, TM0106 family. | 0.501 |
| thyA | AGB16066.1 | Halru_1455 | Halru_1456 | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | PFAM: Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | 0.999 |
| thyA | purD | Halru_1455 | Halru_1452 | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | Phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C domain; TIGRFAM: phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.556 |