| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGB15826.1 | AGB15965.1 | Halru_1211 | Halru_1352 | Diphthine-ammonia ligase; PFAM: ATP-binding region; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.537 |
| AGB15826.1 | AGB16746.1 | Halru_1211 | Halru_2158 | Diphthine-ammonia ligase; PFAM: ATP-binding region; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | 20S proteasome subunit (alpha or beta); Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.447 |
| AGB15826.1 | dphB | Halru_1211 | Halru_1978 | Diphthine-ammonia ligase; PFAM: ATP-binding region; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.831 |
| AGB15826.1 | fusA | Halru_1211 | Halru_0475 | Diphthine-ammonia ligase; PFAM: ATP-binding region; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] | 0.904 |
| AGB15826.1 | psmA | Halru_1211 | Halru_1776 | Diphthine-ammonia ligase; PFAM: ATP-binding region; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | Proteasome endopeptidase complex, archaeal, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.450 |
| AGB15965.1 | AGB15826.1 | Halru_1352 | Halru_1211 | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Diphthine-ammonia ligase; PFAM: ATP-binding region; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | 0.537 |
| AGB15965.1 | AGB16729.1 | Halru_1352 | Halru_2140 | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | PFAM: GTPase of unknown function; TGS domain; TIGRFAM: small GTP-binding protein domain. | 0.605 |
| AGB15965.1 | AGB16746.1 | Halru_1352 | Halru_2158 | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 20S proteasome subunit (alpha or beta); Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.504 |
| AGB15965.1 | dphB | Halru_1352 | Halru_1978 | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.792 |
| AGB15965.1 | fusA | Halru_1352 | Halru_0475 | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] | 0.964 |
| AGB15965.1 | pelA | Halru_1352 | Halru_1998 | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Putative translation factor pelota; May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity. | 0.575 |
| AGB15965.1 | prf1 | Halru_1352 | Halru_2570 | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Peptide chain release factor eRF/aRF, subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. | 0.594 |
| AGB15965.1 | psmA | Halru_1352 | Halru_1776 | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Proteasome endopeptidase complex, archaeal, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.550 |
| AGB15965.1 | rpl19e | Halru_1352 | Halru_1944 | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Ribosomal protein L19E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. | 0.536 |
| AGB15965.1 | rps4e | Halru_1352 | Halru_1950 | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | PFAM: Ribosomal family S4e; RS4NT (NUC023) domain; Belongs to the eukaryotic ribosomal protein eS4 family. | 0.588 |
| AGB16729.1 | AGB15965.1 | Halru_2140 | Halru_1352 | PFAM: GTPase of unknown function; TGS domain; TIGRFAM: small GTP-binding protein domain. | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.605 |
| AGB16729.1 | AGB16746.1 | Halru_2140 | Halru_2158 | PFAM: GTPase of unknown function; TGS domain; TIGRFAM: small GTP-binding protein domain. | 20S proteasome subunit (alpha or beta); Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.660 |
| AGB16729.1 | dphB | Halru_2140 | Halru_1978 | PFAM: GTPase of unknown function; TGS domain; TIGRFAM: small GTP-binding protein domain. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.692 |
| AGB16729.1 | fusA | Halru_2140 | Halru_0475 | PFAM: GTPase of unknown function; TGS domain; TIGRFAM: small GTP-binding protein domain. | Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] | 0.578 |
| AGB16729.1 | pelA | Halru_2140 | Halru_1998 | PFAM: GTPase of unknown function; TGS domain; TIGRFAM: small GTP-binding protein domain. | Putative translation factor pelota; May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity. | 0.476 |
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