| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGB15826.1 | AGB15965.1 | Halru_1211 | Halru_1352 | Diphthine-ammonia ligase; PFAM: ATP-binding region; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.744 |
| AGB15826.1 | dphB | Halru_1211 | Halru_1978 | Diphthine-ammonia ligase; PFAM: ATP-binding region; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.900 |
| AGB15826.1 | eif2b | Halru_1211 | Halru_2349 | Diphthine-ammonia ligase; PFAM: ATP-binding region; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain protein; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. | 0.432 |
| AGB15826.1 | fusA | Halru_1211 | Halru_0475 | Diphthine-ammonia ligase; PFAM: ATP-binding region; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] | 0.935 |
| AGB15965.1 | AGB15826.1 | Halru_1352 | Halru_1211 | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Diphthine-ammonia ligase; PFAM: ATP-binding region; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | 0.744 |
| AGB15965.1 | AGB16578.1 | Halru_1352 | Halru_1983 | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Putative methyltransferase; PFAM: Met-10+ like-protein. | 0.473 |
| AGB15965.1 | AGB16729.1 | Halru_1352 | Halru_2140 | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | PFAM: GTPase of unknown function; TGS domain; TIGRFAM: small GTP-binding protein domain. | 0.607 |
| AGB15965.1 | dphB | Halru_1352 | Halru_1978 | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.890 |
| AGB15965.1 | eif2b | Halru_1352 | Halru_2349 | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain protein; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. | 0.614 |
| AGB15965.1 | fusA | Halru_1352 | Halru_0475 | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] | 0.981 |
| AGB15965.1 | pelA | Halru_1352 | Halru_1998 | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Putative translation factor pelota; May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity. | 0.578 |
| AGB15965.1 | prf1 | Halru_1352 | Halru_2570 | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Peptide chain release factor eRF/aRF, subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. | 0.600 |
| AGB15965.1 | rps4e | Halru_1352 | Halru_1950 | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | PFAM: Ribosomal family S4e; RS4NT (NUC023) domain; Belongs to the eukaryotic ribosomal protein eS4 family. | 0.594 |
| AGB16578.1 | AGB15965.1 | Halru_1983 | Halru_1352 | Putative methyltransferase; PFAM: Met-10+ like-protein. | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.473 |
| AGB16578.1 | dphB | Halru_1983 | Halru_1978 | Putative methyltransferase; PFAM: Met-10+ like-protein. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.775 |
| AGB16578.1 | eif2b | Halru_1983 | Halru_2349 | Putative methyltransferase; PFAM: Met-10+ like-protein. | Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain protein; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. | 0.433 |
| AGB16578.1 | pelA | Halru_1983 | Halru_1998 | Putative methyltransferase; PFAM: Met-10+ like-protein. | Putative translation factor pelota; May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity. | 0.479 |
| AGB16578.1 | prf1 | Halru_1983 | Halru_2570 | Putative methyltransferase; PFAM: Met-10+ like-protein. | Peptide chain release factor eRF/aRF, subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. | 0.605 |
| AGB16578.1 | rps6e | Halru_1983 | Halru_0557 | Putative methyltransferase; PFAM: Met-10+ like-protein. | PFAM: Ribosomal protein S6e; Belongs to the eukaryotic ribosomal protein eS6 family. | 0.436 |
| AGB16729.1 | AGB15965.1 | Halru_2140 | Halru_1352 | PFAM: GTPase of unknown function; TGS domain; TIGRFAM: small GTP-binding protein domain. | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.607 |
