| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGB16884.1 | aroA-2 | Halru_2299 | Halru_2303 | Methylated DNA-protein cysteine methyltransferase; PFAM: 6-O-methylguanine DNA methyltransferase, DNA binding domain. | Putative phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. | 0.769 |
| AGB16884.1 | dtdA | Halru_2299 | Halru_2471 | Methylated DNA-protein cysteine methyltransferase; PFAM: 6-O-methylguanine DNA methyltransferase, DNA binding domain. | Hypothetical protein; D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo. | 0.510 |
| AGB16884.1 | nadK-2 | Halru_2299 | Halru_1658 | Methylated DNA-protein cysteine methyltransferase; PFAM: 6-O-methylguanine DNA methyltransferase, DNA binding domain. | Inositol monophosphatase/fructose-1,6-bisphosphatase family protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.424 |
| AGB16884.1 | trpA | Halru_2299 | Halru_2302 | Methylated DNA-protein cysteine methyltransferase; PFAM: 6-O-methylguanine DNA methyltransferase, DNA binding domain. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.799 |
| AGB16884.1 | trpB | Halru_2299 | Halru_2301 | Methylated DNA-protein cysteine methyltransferase; PFAM: 6-O-methylguanine DNA methyltransferase, DNA binding domain. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.592 |
| AGB16884.1 | trpC | Halru_2299 | Halru_2300 | Methylated DNA-protein cysteine methyltransferase; PFAM: 6-O-methylguanine DNA methyltransferase, DNA binding domain. | PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.799 |
| aroA-2 | AGB16884.1 | Halru_2303 | Halru_2299 | Putative phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. | Methylated DNA-protein cysteine methyltransferase; PFAM: 6-O-methylguanine DNA methyltransferase, DNA binding domain. | 0.769 |
| aroA-2 | trpA | Halru_2303 | Halru_2302 | Putative phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.976 |
| aroA-2 | trpB | Halru_2303 | Halru_2301 | Putative phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.959 |
| aroA-2 | trpC | Halru_2303 | Halru_2300 | Putative phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. | PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.972 |
| dtdA | AGB16884.1 | Halru_2471 | Halru_2299 | Hypothetical protein; D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo. | Methylated DNA-protein cysteine methyltransferase; PFAM: 6-O-methylguanine DNA methyltransferase, DNA binding domain. | 0.510 |
| dtdA | trpA | Halru_2471 | Halru_2302 | Hypothetical protein; D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.450 |
| nadK-2 | AGB16884.1 | Halru_1658 | Halru_2299 | Inositol monophosphatase/fructose-1,6-bisphosphatase family protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Methylated DNA-protein cysteine methyltransferase; PFAM: 6-O-methylguanine DNA methyltransferase, DNA binding domain. | 0.424 |
| nadK-2 | trpC | Halru_1658 | Halru_2300 | Inositol monophosphatase/fructose-1,6-bisphosphatase family protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.493 |
| trpA | AGB16884.1 | Halru_2302 | Halru_2299 | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | Methylated DNA-protein cysteine methyltransferase; PFAM: 6-O-methylguanine DNA methyltransferase, DNA binding domain. | 0.799 |
| trpA | aroA-2 | Halru_2302 | Halru_2303 | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | Putative phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. | 0.976 |
| trpA | dtdA | Halru_2302 | Halru_2471 | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | Hypothetical protein; D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo. | 0.450 |
| trpA | trpB | Halru_2302 | Halru_2301 | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.999 |
| trpA | trpC | Halru_2302 | Halru_2300 | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.999 |
| trpB | AGB16884.1 | Halru_2301 | Halru_2299 | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | Methylated DNA-protein cysteine methyltransferase; PFAM: 6-O-methylguanine DNA methyltransferase, DNA binding domain. | 0.592 |