Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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co-expression
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nfoApurinic endonuclease APN1; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (289 aa)    
Predicted Functional Partners:
AGB16963.1
Methylase involved in ubiquinone/menaquinone biosynthesis; PFAM: Methyltransferase domain.
       0.854
AGB16961.1
PFAM: Biotin/lipoate A/B protein ligase family.
       0.814
AGB17633.1
Secreted protein with C-terminal beta-propeller domain; PFAM: Beta propeller domain.
   
 
 0.812
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
  
 
 0.786
AGB16503.1
Putative endoIII-related endonuclease; PFAM: HhH-GPD superfamily base excision DNA repair protein; Iron-sulfur binding domain of endonuclease III; Helix-hairpin-helix motif.
  
 
 0.786
AGB15940.1
PFAM: HhH-GPD superfamily base excision DNA repair protein.
   
 
 0.632
AGB16739.1
PFAM: 8-oxoguanine DNA glycosylase, N-terminal domain; HhH-GPD superfamily base excision DNA repair protein; TIGRFAM: 8-oxoguanine DNA-glycosylase (ogg).
   
 
 0.632
AGB15795.1
DNA polymerase elongation subunit (family B); PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain.
 
 
 
 0.579
fen
Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...]
  
 
 0.572
AGB16328.1
Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.
  
  
 0.528
Your Current Organism:
Halovivax ruber
NCBI taxonomy Id: 797302
Other names: H. ruber XH-70, Halovivax ruber JCM 13892, Halovivax ruber XH-70, Halovivax ruber str. XH-70, Halovivax ruber strain XH-70
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