| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGB14734.1 | AGB17425.1 | Halru_0082 | Halru_2855 | Ribonuclease H, mammalian HI/archaeal HII subfamily; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | Hypothetical protein. | 0.673 |
| AGB14734.1 | fen | Halru_0082 | Halru_0771 | Ribonuclease H, mammalian HI/archaeal HII subfamily; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.956 |
| AGB14734.1 | radA | Halru_0082 | Halru_2758 | Ribonuclease H, mammalian HI/archaeal HII subfamily; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.772 |
| AGB14734.1 | radB | Halru_0082 | Halru_2138 | Ribonuclease H, mammalian HI/archaeal HII subfamily; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | DNA repair and recombination protein RadB; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange. | 0.758 |
| AGB14734.1 | top6A | Halru_0082 | Halru_1442 | Ribonuclease H, mammalian HI/archaeal HII subfamily; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | DNA topoisomerase VI, subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. | 0.452 |
| AGB14734.1 | topA | Halru_0082 | Halru_1101 | Ribonuclease H, mammalian HI/archaeal HII subfamily; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | Topoisomerase IA; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA superco [...] | 0.433 |
| AGB16489.1 | AGB17425.1 | Halru_1891 | Halru_2855 | PFAM: Protein kinase domain; FHA domain. | Hypothetical protein. | 0.814 |
| AGB16489.1 | AGB17426.1 | Halru_1891 | Halru_2856 | PFAM: Protein kinase domain; FHA domain. | DNA repair exonuclease; PFAM: Calcineurin-like phosphoesterase. | 0.736 |
| AGB16489.1 | fen | Halru_1891 | Halru_0771 | PFAM: Protein kinase domain; FHA domain. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.514 |
| AGB16489.1 | mre11 | Halru_1891 | Halru_1173 | PFAM: Protein kinase domain; FHA domain. | DNA repair exonuclease; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity; Belongs to the MRE11/RAD32 family. | 0.736 |
| AGB16489.1 | radA | Halru_1891 | Halru_2758 | PFAM: Protein kinase domain; FHA domain. | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.528 |
| AGB16489.1 | radB | Halru_1891 | Halru_2138 | PFAM: Protein kinase domain; FHA domain. | DNA repair and recombination protein RadB; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange. | 0.528 |
| AGB17425.1 | AGB14734.1 | Halru_2855 | Halru_0082 | Hypothetical protein. | Ribonuclease H, mammalian HI/archaeal HII subfamily; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.673 |
| AGB17425.1 | AGB16489.1 | Halru_2855 | Halru_1891 | Hypothetical protein. | PFAM: Protein kinase domain; FHA domain. | 0.814 |
| AGB17425.1 | AGB17426.1 | Halru_2855 | Halru_2856 | Hypothetical protein. | DNA repair exonuclease; PFAM: Calcineurin-like phosphoesterase. | 0.994 |
| AGB17425.1 | fen | Halru_2855 | Halru_0771 | Hypothetical protein. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.933 |
| AGB17425.1 | mre11 | Halru_2855 | Halru_1173 | Hypothetical protein. | DNA repair exonuclease; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity; Belongs to the MRE11/RAD32 family. | 0.962 |
| AGB17425.1 | rad25 | Halru_2855 | Halru_1625 | Hypothetical protein. | DNA/RNA helicase, superfamily II; PFAM: Helicase conserved C-terminal domain; Type III restriction enzyme, res subunit. | 0.670 |
| AGB17425.1 | radA | Halru_2855 | Halru_2758 | Hypothetical protein. | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.780 |
| AGB17425.1 | radB | Halru_2855 | Halru_2138 | Hypothetical protein. | DNA repair and recombination protein RadB; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange. | 0.780 |
