| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGB30543.1 | dacZ | Natpe_0618 | Natpe_1223 | Dihydropteroate synthase; PFAM: Pterin binding enzyme; Mur ligase family, glutamate ligase domain; Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase; dihydropteroate synthase. | Hypothetical protein; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. | 0.505 |
| AGB31128.1 | AGB32291.1 | Natpe_1222 | Natpe_2477 | PFAM: Mechanosensitive ion channel. | PFAM: CYTH domain; TIGRFAM: adenylyl cyclase CyaB, putative. | 0.586 |
| AGB31128.1 | dacZ | Natpe_1222 | Natpe_1223 | PFAM: Mechanosensitive ion channel. | Hypothetical protein; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. | 0.932 |
| AGB32148.1 | AGB33061.1 | Natpe_2330 | Natpe_3273 | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | PFAM: ATP-binding region; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | 0.760 |
| AGB32148.1 | dacZ | Natpe_2330 | Natpe_1223 | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Hypothetical protein; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. | 0.541 |
| AGB32148.1 | hisC | Natpe_2330 | Natpe_2228 | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase. | 0.429 |
| AGB32148.1 | mptA | Natpe_2330 | Natpe_3511 | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | TIGR00294 family protein; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. | 0.581 |
| AGB32148.1 | nadK | Natpe_2330 | Natpe_3507 | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Putative sugar kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.546 |
| AGB32148.1 | rpl37ae | Natpe_2330 | Natpe_2960 | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Ribosomal protein L37AE/L43A; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL43 family. | 0.558 |
| AGB32262.1 | dacZ | Natpe_2446 | Natpe_1223 | Exopolyphosphatase-like enzyme; PFAM: DHH family; TrkA-N domain. | Hypothetical protein; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. | 0.529 |
| AGB32291.1 | AGB31128.1 | Natpe_2477 | Natpe_1222 | PFAM: CYTH domain; TIGRFAM: adenylyl cyclase CyaB, putative. | PFAM: Mechanosensitive ion channel. | 0.586 |
| AGB32291.1 | dacZ | Natpe_2477 | Natpe_1223 | PFAM: CYTH domain; TIGRFAM: adenylyl cyclase CyaB, putative. | Hypothetical protein; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. | 0.695 |
| AGB32291.1 | mptA | Natpe_2477 | Natpe_3511 | PFAM: CYTH domain; TIGRFAM: adenylyl cyclase CyaB, putative. | TIGR00294 family protein; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. | 0.800 |
| AGB33061.1 | AGB32148.1 | Natpe_3273 | Natpe_2330 | PFAM: ATP-binding region; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.760 |
| AGB33061.1 | dacZ | Natpe_3273 | Natpe_1223 | PFAM: ATP-binding region; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | Hypothetical protein; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. | 0.520 |
| AGB33061.1 | hisC | Natpe_3273 | Natpe_2228 | PFAM: ATP-binding region; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase. | 0.493 |
| AGB33061.1 | mptA | Natpe_3273 | Natpe_3511 | PFAM: ATP-binding region; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | TIGR00294 family protein; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. | 0.515 |
| AGB33061.1 | nadK | Natpe_3273 | Natpe_3507 | PFAM: ATP-binding region; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | Putative sugar kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.515 |
| AGB33061.1 | rpl37ae | Natpe_3273 | Natpe_2960 | PFAM: ATP-binding region; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | Ribosomal protein L37AE/L43A; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL43 family. | 0.463 |
| dacZ | AGB30543.1 | Natpe_1223 | Natpe_0618 | Hypothetical protein; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. | Dihydropteroate synthase; PFAM: Pterin binding enzyme; Mur ligase family, glutamate ligase domain; Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase; dihydropteroate synthase. | 0.505 |
