| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| eif1a | psmA | Natpe_0107 | Natpe_1510 | Eukaryotic/archaeal initiation factor 1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. | Proteasome endopeptidase complex, archaeal, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.780 |
| eif1a | psmA-2 | Natpe_0107 | Natpe_2518 | Eukaryotic/archaeal initiation factor 1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. | Proteasome endopeptidase complex, archaeal, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.788 |
| eif1a | psmB | Natpe_0107 | Natpe_1509 | Eukaryotic/archaeal initiation factor 1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. | Proteasome endopeptidase complex, archaeal, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.635 |
| eif1a | psmB-2 | Natpe_0107 | Natpe_2576 | Eukaryotic/archaeal initiation factor 1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. | Proteasome endopeptidase complex, archaeal, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.611 |
| eif1a | rpl15e | Natpe_0107 | Natpe_0791 | Eukaryotic/archaeal initiation factor 1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. | Ribosomal protein L15E; PFAM: Ribosomal L15; Belongs to the eukaryotic ribosomal protein eL15 family. | 0.917 |
| eif1a | rpl4lp | Natpe_0107 | Natpe_0871 | Eukaryotic/archaeal initiation factor 1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. | 50S ribosomal protein L4P; Forms part of the polypeptide exit tunnel. | 0.823 |
| eif1a | rps4e | Natpe_0107 | Natpe_0882 | Eukaryotic/archaeal initiation factor 1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. | PFAM: Ribosomal family S4e; RS4NT (NUC023) domain; Belongs to the eukaryotic ribosomal protein eS4 family. | 0.953 |
| glpK | pan | Natpe_1013 | Natpe_0359 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. | 26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] | 0.903 |
| glpK | pan-2 | Natpe_1013 | Natpe_2784 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. | 26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] | 0.903 |
| glpK | psmA | Natpe_1013 | Natpe_1510 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. | Proteasome endopeptidase complex, archaeal, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.772 |
| glpK | psmA-2 | Natpe_1013 | Natpe_2518 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. | Proteasome endopeptidase complex, archaeal, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.772 |
| glpK | psmB | Natpe_1013 | Natpe_1509 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. | Proteasome endopeptidase complex, archaeal, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.772 |
| glpK | psmB-2 | Natpe_1013 | Natpe_2576 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. | Proteasome endopeptidase complex, archaeal, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.772 |
| glpK | rps4e | Natpe_1013 | Natpe_0882 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. | PFAM: Ribosomal family S4e; RS4NT (NUC023) domain; Belongs to the eukaryotic ribosomal protein eS4 family. | 0.490 |
| pan | glpK | Natpe_0359 | Natpe_1013 | 26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. | 0.903 |
| pan | pan-2 | Natpe_0359 | Natpe_2784 | 26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] | 26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] | 0.902 |
| pan | psmA | Natpe_0359 | Natpe_1510 | 26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] | Proteasome endopeptidase complex, archaeal, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.850 |
| pan | psmA-2 | Natpe_0359 | Natpe_2518 | 26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] | Proteasome endopeptidase complex, archaeal, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.852 |
| pan | psmB | Natpe_0359 | Natpe_1509 | 26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] | Proteasome endopeptidase complex, archaeal, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.841 |
| pan | psmB-2 | Natpe_0359 | Natpe_2576 | 26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] | Proteasome endopeptidase complex, archaeal, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.841 |
