| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGB30135.1 | hisA | Natpe_0195 | Natpe_0057 | PFAM: Prephenate dehydratase; ACT domain. | PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.464 |
| AGB30135.1 | hisB | Natpe_0195 | Natpe_0055 | PFAM: Prephenate dehydratase; ACT domain. | PFAM: Imidazoleglycerol-phosphate dehydratase. | 0.493 |
| AGB30135.1 | hisC | Natpe_0195 | Natpe_2228 | PFAM: Prephenate dehydratase; ACT domain. | PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase. | 0.939 |
| AGB30135.1 | hisF | Natpe_0195 | Natpe_2340 | PFAM: Prephenate dehydratase; ACT domain. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.458 |
| AGB30135.1 | hisG | Natpe_0195 | Natpe_0117 | PFAM: Prephenate dehydratase; ACT domain. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.438 |
| AGB30135.1 | hisH | Natpe_0195 | Natpe_1038 | PFAM: Prephenate dehydratase; ACT domain. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.527 |
| AGB32051.1 | AGB32052.1 | Natpe_2226 | Natpe_2227 | Phosphatidylglycerophosphate synthase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Putative nucleoside kinase, CMP and AMP kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. | 0.968 |
| AGB32051.1 | hisC | Natpe_2226 | Natpe_2228 | Phosphatidylglycerophosphate synthase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase. | 0.972 |
| AGB32051.1 | hisG | Natpe_2226 | Natpe_0117 | Phosphatidylglycerophosphate synthase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.471 |
| AGB32052.1 | AGB32051.1 | Natpe_2227 | Natpe_2226 | Putative nucleoside kinase, CMP and AMP kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. | Phosphatidylglycerophosphate synthase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.968 |
| AGB32052.1 | hisC | Natpe_2227 | Natpe_2228 | Putative nucleoside kinase, CMP and AMP kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. | PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase. | 0.966 |
| hisA | AGB30135.1 | Natpe_0057 | Natpe_0195 | PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | PFAM: Prephenate dehydratase; ACT domain. | 0.464 |
| hisA | hisB | Natpe_0057 | Natpe_0055 | PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | PFAM: Imidazoleglycerol-phosphate dehydratase. | 0.984 |
| hisA | hisC | Natpe_0057 | Natpe_2228 | PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase. | 0.940 |
| hisA | hisD | Natpe_0057 | Natpe_2260 | PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.996 |
| hisA | hisF | Natpe_0057 | Natpe_2340 | PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.996 |
| hisA | hisG | Natpe_0057 | Natpe_0117 | PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.981 |
| hisA | hisH | Natpe_0057 | Natpe_1038 | PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
| hisA | hisI | Natpe_0057 | Natpe_0085 | PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
| hisB | AGB30135.1 | Natpe_0055 | Natpe_0195 | PFAM: Imidazoleglycerol-phosphate dehydratase. | PFAM: Prephenate dehydratase; ACT domain. | 0.493 |
