Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AFZ71618.1PFAM: Mechanosensitive ion channel. (254 aa)    
Predicted Functional Partners:
dacZ
Hypothetical protein; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.
 
   
 0.954
cyaB
PFAM: CYTH domain; TIGRFAM: adenylyl cyclase CyaB, putative.
  
   
 0.609
AFZ72692.1
NMD protein affecting ribosome stability and mRNA decay; PFAM: NMD3 family.
   
    0.565
AFZ73281.1
NhaP-type Na+(K+)/H+ antiporter; PFAM: TrkA-N domain; Sodium/hydrogen exchanger family; TrkA-C domain.
 
   
 0.527
AFZ74281.1
NhaP-type Na+(K+)/H+ antiporter; PFAM: TrkA-N domain; TrkA-C domain; Sodium/hydrogen exchanger family.
 
   
 0.527
AFZ74904.1
PFAM: Mechanosensitive ion channel.
  
     0.526
AFZ72865.1
Glutathione synthase/ribosomal protein S6 modification enzyme (glutaminyl transferase); PFAM: RimK-like ATP-grasp domain; TIGRFAM: alpha-L-glutamate ligases, RimK family.
 
     0.478
AFZ73324.1
PFAM: Mechanosensitive ion channel.
  
     0.477
pyk
PFAM: Pyruvate kinase, barrel domain; PEP-utilising enzyme, mobile domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family.
   
  
 0.446
AFZ71969.1
PFAM: Mechanosensitive ion channel.
  
     0.443
Your Current Organism:
Natronobacterium gregoryi
NCBI taxonomy Id: 797304
Other names: N. gregoryi SP2, Natronobacterium gregoryi ATCC 43098, Natronobacterium gregoryi JCM 8860, Natronobacterium gregoryi NCIMB 2189, Natronobacterium gregoryi SP2, Natronobacterium gregoryi str. SP2, Natronobacterium gregoryi strain SP2
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