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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
acsacetate--CoA ligase; PFAM: Domain of unknown function (DUF3448); AMP-binding enzyme; TIGRFAM: acetate--CoA ligase. (656 aa)    
Predicted Functional Partners:
AFZ74812.1
PFAM: Citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II.
  
 0.969
AFZ73487.1
PFAM: Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family.
  
 0.955
AFZ73818.1
PFAM: Aldehyde dehydrogenase family.
  
 0.955
AFZ74360.1
PFAM: CoA binding domain; ATP-grasp domain; TIGRFAM: acetyl coenzyme A synthetase (ADP forming), alpha domain.
    
 0.953
AFZ73358.1
PFAM: Acetyl-CoA hydrolase/transferase N-terminal domain; Citrate lyase, alpha subunit (CitF).
  
 0.942
AFZ71847.1
acetyl/propionyl-CoA carboxylase, alpha subunit; PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; Biotin carboxylase C-terminal domain; Carbamoyl-phosphate synthase L chain, N-terminal domain; Biotin-requiring enzyme; TIGRFAM: acetyl-CoA carboxylase, biotin carboxylase subunit.
  
 0.929
AFZ71849.1
acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta); PFAM: Carboxyl transferase domain.
  
 0.927
AFZ71346.1
Isopropylmalate/homocitrate/citramalate synthase; PFAM: HMGL-like; manually curated; non-canonical start codon; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 
 0.926
acs-2
acetate--CoA ligase; PFAM: Domain of unknown function (DUF3448); AMP-binding enzyme; TIGRFAM: acetate--CoA ligase.
 
  
 
0.926
AFZ72788.1
acyl-CoA synthetase/AMP-acid ligase; PFAM: AMP-binding enzyme.
  
 
0.921
Your Current Organism:
Natronobacterium gregoryi
NCBI taxonomy Id: 797304
Other names: N. gregoryi SP2, Natronobacterium gregoryi ATCC 43098, Natronobacterium gregoryi JCM 8860, Natronobacterium gregoryi NCIMB 2189, Natronobacterium gregoryi SP2, Natronobacterium gregoryi str. SP2, Natronobacterium gregoryi strain SP2
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