| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AFZ71677.1 | AFZ72007.1 | Natgr_0422 | Natgr_0765 | PFAM: 2Fe-2S iron-sulfur cluster binding domain; Universal stress protein family. | Methylated DNA-protein cysteine methyltransferase; PFAM: 6-O-methylguanine DNA methyltransferase, DNA binding domain. | 0.454 |
| AFZ72007.1 | AFZ71677.1 | Natgr_0765 | Natgr_0422 | Methylated DNA-protein cysteine methyltransferase; PFAM: 6-O-methylguanine DNA methyltransferase, DNA binding domain. | PFAM: 2Fe-2S iron-sulfur cluster binding domain; Universal stress protein family. | 0.454 |
| AFZ72007.1 | AFZ72199.1 | Natgr_0765 | Natgr_0968 | Methylated DNA-protein cysteine methyltransferase; PFAM: 6-O-methylguanine DNA methyltransferase, DNA binding domain. | Hypothetical protein. | 0.511 |
| AFZ72007.1 | aroA | Natgr_0765 | Natgr_0761 | Methylated DNA-protein cysteine methyltransferase; PFAM: 6-O-methylguanine DNA methyltransferase, DNA binding domain. | Putative phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. | 0.631 |
| AFZ72007.1 | fen | Natgr_0765 | Natgr_0722 | Methylated DNA-protein cysteine methyltransferase; PFAM: 6-O-methylguanine DNA methyltransferase, DNA binding domain. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.496 |
| AFZ72007.1 | trpA | Natgr_0765 | Natgr_0762 | Methylated DNA-protein cysteine methyltransferase; PFAM: 6-O-methylguanine DNA methyltransferase, DNA binding domain. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.671 |
| AFZ72007.1 | trpB | Natgr_0765 | Natgr_0763 | Methylated DNA-protein cysteine methyltransferase; PFAM: 6-O-methylguanine DNA methyltransferase, DNA binding domain. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.597 |
| AFZ72007.1 | trpC | Natgr_0765 | Natgr_0764 | Methylated DNA-protein cysteine methyltransferase; PFAM: 6-O-methylguanine DNA methyltransferase, DNA binding domain. | PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.671 |
| AFZ72007.1 | truA | Natgr_0765 | Natgr_2266 | Methylated DNA-protein cysteine methyltransferase; PFAM: 6-O-methylguanine DNA methyltransferase, DNA binding domain. | Pseudouridylate synthase; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs; Belongs to the tRNA pseudouridine synthase TruA family. | 0.519 |
| AFZ72007.1 | uvrB | Natgr_0765 | Natgr_1510 | Methylated DNA-protein cysteine methyltransferase; PFAM: 6-O-methylguanine DNA methyltransferase, DNA binding domain. | Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.499 |
| AFZ72007.1 | uvrC | Natgr_0765 | Natgr_1717 | Methylated DNA-protein cysteine methyltransferase; PFAM: 6-O-methylguanine DNA methyltransferase, DNA binding domain. | Excinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.515 |
| AFZ72199.1 | AFZ72007.1 | Natgr_0968 | Natgr_0765 | Hypothetical protein. | Methylated DNA-protein cysteine methyltransferase; PFAM: 6-O-methylguanine DNA methyltransferase, DNA binding domain. | 0.511 |
| AFZ72199.1 | uvrC | Natgr_0968 | Natgr_1717 | Hypothetical protein. | Excinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.403 |
| aroA | AFZ72007.1 | Natgr_0761 | Natgr_0765 | Putative phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. | Methylated DNA-protein cysteine methyltransferase; PFAM: 6-O-methylguanine DNA methyltransferase, DNA binding domain. | 0.631 |
| aroA | trpA | Natgr_0761 | Natgr_0762 | Putative phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.932 |
| aroA | trpB | Natgr_0761 | Natgr_0763 | Putative phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.805 |
| aroA | trpC | Natgr_0761 | Natgr_0764 | Putative phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. | PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.816 |
| fen | AFZ72007.1 | Natgr_0722 | Natgr_0765 | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | Methylated DNA-protein cysteine methyltransferase; PFAM: 6-O-methylguanine DNA methyltransferase, DNA binding domain. | 0.496 |
| fen | trpA | Natgr_0722 | Natgr_0762 | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.685 |
| fen | uvrB | Natgr_0722 | Natgr_1510 | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.574 |
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