Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AFZ72190.1Zn-dependent protease with chaperone function; PFAM: Peptidase family M48. (436 aa)    
Predicted Functional Partners:
AFZ73271.1
Putative kinase, sugar kinase superfamily; PFAM: GHMP kinases N terminal domain.
  
    0.595
AFZ72436.1
PFAM: Pyridine nucleotide-disulphide oxidoreductase; NADH:flavin oxidoreductase / NADH oxidase family.
  
 
 0.581
AFZ72191.1
Zn-dependent protease with chaperone function; PFAM: Peptidase family M48.
 
    
0.569
alaS
alanine--tRNA ligase/alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
  
    0.561
AFZ72907.1
PFAM: lactate/malate dehydrogenase, alpha/beta C-terminal domain; lactate/malate dehydrogenase, NAD binding domain; Belongs to the LDH/MDH superfamily.
  
 0.540
AFZ73356.1
Putative metal-dependent hydrolase related to alanyl-tRNA synthetase HxxxH domain protein; PFAM: Threonyl and Alanyl tRNA synthetase second additional domain; tRNA synthetases class II (A).
  
    0.520
AFZ74062.1
alanyl-tRNA synthetase; PFAM: DHHA1 domain; Threonyl and Alanyl tRNA synthetase second additional domain; tRNA synthetases class II (A).
  
    0.520
fumC
Fumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 
 0.492
sucC
succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 
 0.491
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P).
  
 0.468
Your Current Organism:
Natronobacterium gregoryi
NCBI taxonomy Id: 797304
Other names: N. gregoryi SP2, Natronobacterium gregoryi ATCC 43098, Natronobacterium gregoryi JCM 8860, Natronobacterium gregoryi NCIMB 2189, Natronobacterium gregoryi SP2, Natronobacterium gregoryi str. SP2, Natronobacterium gregoryi strain SP2
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