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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
polCDNA polymerase type II, large subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. (1211 aa)    
Predicted Functional Partners:
polB
Archaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family.
 
 
 
 0.961
AFZ72659.1
Putative DNA-binding protein with PD1-like DNA-binding motif; PFAM: Domain of unknown function (DUF296).
       0.836
pcn
DNA polymerase sliding clamp subunit; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
 
 
 
 0.813
AFZ73808.1
PFAM: Proliferating cell nuclear antigen, N-terminal domain.
   
 
 0.752
AFZ71593.1
ATP-grasp superfamily enzyme; PFAM: PAC2 family; TIGRFAM: TIGR00161 family protein.
  
     0.725
AFZ72031.1
PFAM: PAC2 family; TIGRFAM: TIGR00162 family protein.
  
     0.722
nac
alpha-NAC-related protein; Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family.
  
     0.722
AFZ72666.1
Single-stranded DNA-specific exonuclease; PFAM: DHHA1 domain; DHH family.
 
     0.718
AFZ72799.1
Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication.
 
   
 0.717
nusG
Ribosomal protein L24p/L26e, archaeal; Stimulates transcription elongation; Belongs to the archaeal Spt5 family.
  
     0.703
Your Current Organism:
Natronobacterium gregoryi
NCBI taxonomy Id: 797304
Other names: N. gregoryi SP2, Natronobacterium gregoryi ATCC 43098, Natronobacterium gregoryi JCM 8860, Natronobacterium gregoryi NCIMB 2189, Natronobacterium gregoryi SP2, Natronobacterium gregoryi str. SP2, Natronobacterium gregoryi strain SP2
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