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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rrmJ23S rRNA methylase; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. (260 aa)    
Predicted Functional Partners:
rpl30p
PFAM: Ribosomal protein L30p/L7e; TIGRFAM: 50S ribosomal protein L30P, archaeal.
   
 
 0.983
rpl3p
Archaeal ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.
  
 
 0.978
rpl22p
Ribosomal protein L22/L17; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
  
   0.976
rpl18e
PFAM: Ribosomal protein L18e/L15; Belongs to the eukaryotic ribosomal protein eL18 family.
   
   0.976
AFZ71452.1
rRNA biogenesis protein; PFAM: Putative snoRNA binding domain; BAAT / Acyl-CoA thioester hydrolase C terminal.
 
 0.959
AFZ73210.1
Putative GTPase; PFAM: Nucleolar GTP-binding protein 1 (NOG1); TIGRFAM: small GTP-binding protein domain.
   
 
 0.935
rps8e
PFAM: Ribosomal protein S8e; TIGRFAM: ribosomal protein S8.e.
  
 
 0.924
AFZ74730.1
PFAM: NOL1/NOP2/sun family; TIGRFAM: NOL1/NOP2/sun family putative RNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
  
 
 0.910
flpA
Fibrillarin-like rRNA methylase; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family.
  
 0.880
rpl2p
Ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.
    
 
 0.846
Your Current Organism:
Natronobacterium gregoryi
NCBI taxonomy Id: 797304
Other names: N. gregoryi SP2, Natronobacterium gregoryi ATCC 43098, Natronobacterium gregoryi JCM 8860, Natronobacterium gregoryi NCIMB 2189, Natronobacterium gregoryi SP2, Natronobacterium gregoryi str. SP2, Natronobacterium gregoryi strain SP2
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