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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AFZ72834.1GMP synthase family protein; PFAM: Glutamine amidotransferase class-I. (246 aa)    
Predicted Functional Partners:
AFZ73954.1
PFAM: IMP dehydrogenase / GMP reductase domain; TIGRFAM: guanosine monophosphate reductase, eukaryotic.
 
 
 0.978
guaB
Inosine-5''-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
 
 0.976
guaAB
GMP synthase, glutamine-hydrolyzing, C-terminal domain or B subunit; Catalyzes the synthesis of GMP from XMP.
 
  
 0.971
AFZ73643.1
PRPP-binding protein, adenine/guanine phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain.
 
 
 0.949
AFZ72053.1
PRPP-binding protein, adenine/guanine phosphoribosyltransferase; May catalyze a purine salvage reaction, the substrate is unknown.
 
 
 0.945
rdgB
PFAM: Ham1 family; TIGRFAM: non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Belongs to the HAM1 NTPase family.
 
 
 0.931
guaAA
GMP synthase, glutamine-hydrolyzing, N-terminal domain or A subunit; Catalyzes the synthesis of GMP from XMP.
  
  
 
0.922
surE
5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.920
surE-2
5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.920
AFZ72225.1
AICAR transformylase/IMP cyclohydrolase PurH; PFAM: AICARFT/IMPCHase bienzyme; Formyl transferase; TIGRFAM: phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent.
 
  
 0.826
Your Current Organism:
Natronobacterium gregoryi
NCBI taxonomy Id: 797304
Other names: N. gregoryi SP2, Natronobacterium gregoryi ATCC 43098, Natronobacterium gregoryi JCM 8860, Natronobacterium gregoryi NCIMB 2189, Natronobacterium gregoryi SP2, Natronobacterium gregoryi str. SP2, Natronobacterium gregoryi strain SP2
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