close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AFZ72864.1Molecular chaperone (small heat shock protein); PFAM: GvpH; Belongs to the small heat shock protein (HSP20) family. (133 aa)    
Predicted Functional Partners:
gap-2
Glyceraldehyde-3-phosphate dehydrogenase, type II; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type II.
 
 
 0.694
dnaK
Chaperone protein DnaK; Acts as a chaperone.
  
 
 0.634
AFZ74817.1
AAA family ATPase, CDC48 subfamily; PFAM: Cell division protein 48 (CDC48), N-terminal domain; ATPase family associated with various cellular activities (AAA); Cell division protein 48 (CDC48), domain 2; TIGRFAM: AAA family ATPase, CDC48 subfamily.
 
  
 0.607
AFZ74414.1
AAA+ family ATPase; PFAM: Cell division protein 48 (CDC48), N-terminal domain; ATPase family associated with various cellular activities (AAA); Cell division protein 48 (CDC48), domain 2; TIGRFAM: AAA family ATPase, CDC48 subfamily.
 
  
 0.600
AFZ74850.1
AAA family ATPase, CDC48 subfamily; PFAM: Cell division protein 48 (CDC48), N-terminal domain; ATPase family associated with various cellular activities (AAA); Cell division protein 48 (CDC48), domain 2; TIGRFAM: AAA family ATPase, CDC48 subfamily.
 
  
 0.599
grpE
Molecular chaperone GrpE (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. [...]
  
  
 0.558
fxsA
Protein affecting phage T7 exclusion by the F plasmid; PFAM: FxsA cytoplasmic membrane protein.
   
    0.475
AFZ74207.1
PFAM: Gas vesicle protein K.
 
    0.456
AFZ74208.1
Gas vesicle protein; Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth.
 
     0.453
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
  
 
 0.452
Your Current Organism:
Natronobacterium gregoryi
NCBI taxonomy Id: 797304
Other names: N. gregoryi SP2, Natronobacterium gregoryi ATCC 43098, Natronobacterium gregoryi JCM 8860, Natronobacterium gregoryi NCIMB 2189, Natronobacterium gregoryi SP2, Natronobacterium gregoryi str. SP2, Natronobacterium gregoryi strain SP2
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.