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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AFZ73154.1Hypothetical protein; PFAM: Pyruvoyl-dependent arginine decarboxylase (PvlArgDC); TIGRFAM: arginine decarboxylase, pyruvoyl-dependent. (165 aa)    
Predicted Functional Partners:
speB
Agmatinase; PFAM: Arginase family; TIGRFAM: agmatinase; Belongs to the arginase family.
    
 0.925
AFZ73990.1
Nitric oxide synthase, oxygenase domain protein; Catalyzes the production of nitric oxide. Belongs to the NOS family. Bacterial NOS oxygenase subfamily.
     
  0.900
AFZ71934.1
Arginine deiminase; PFAM: Amidinotransferase.
    
  0.807
argH
PFAM: Lyase; TIGRFAM: argininosuccinate lyase.
     
 0.800
AFZ73155.1
Hypothetical protein.
       0.694
AFZ72511.1
Histones H3 and H4; PFAM: Histone-like transcription factor (CBF/NF-Y) and archaeal histone.
  
   
 0.585
pan-2
26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...]
       0.576
purO
IMP cyclohydrolase; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP.
  
     0.558
AFZ72704.1
DNA helicase, Rad3; PFAM: DEAD_2.
  
     0.557
gch3
Hypothetical protein; Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity; Belongs to the archaeal-type GTP cyclohydrolase family.
  
     0.545
Your Current Organism:
Natronobacterium gregoryi
NCBI taxonomy Id: 797304
Other names: N. gregoryi SP2, Natronobacterium gregoryi ATCC 43098, Natronobacterium gregoryi JCM 8860, Natronobacterium gregoryi NCIMB 2189, Natronobacterium gregoryi SP2, Natronobacterium gregoryi str. SP2, Natronobacterium gregoryi strain SP2
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