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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AFZ74535.1Putative ATPase involved in replication control, Cdc46/Mcm family; PFAM: MCM2/3/5 family; Belongs to the MCM family. (709 aa)    
Predicted Functional Partners:
AFZ74650.1
Putative ATPase involved in replication control, Cdc46/Mcm family; PFAM: MCM2/3/5 family; Belongs to the MCM family.
  
  
 
0.923
AFZ72934.1
Putative ATPase involved in replication control, Cdc46/Mcm family; PFAM: Helix-turn-helix; MCM2/3/5 family; TIGRFAM: intein N-terminal splicing region; intein C-terminal splicing region.
  
  
 
0.904
AFZ71818.1
DNA polymerase elongation subunit (family B); PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain.
  
 0.893
fen
Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...]
  
 
 0.869
cdc6
Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication.
 
 0.844
AFZ72799.1
Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication.
 
 0.841
AFZ74594.1
Cdc6-related protein, AAA superfamily ATPase; PFAM: ATPase family associated with various cellular activities (AAA).
 
 0.836
rfc
DNA polymerase III, gamma/tau subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily.
 
 
 0.827
AFZ73070.1
Cdc6-related protein, AAA superfamily ATPase; PFAM: ATPase family associated with various cellular activities (AAA).
 
 0.816
priS
DNA primase, eukaryotic-type, small subunit, putative; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extens [...]
  
 0.801
Your Current Organism:
Natronobacterium gregoryi
NCBI taxonomy Id: 797304
Other names: N. gregoryi SP2, Natronobacterium gregoryi ATCC 43098, Natronobacterium gregoryi JCM 8860, Natronobacterium gregoryi NCIMB 2189, Natronobacterium gregoryi SP2, Natronobacterium gregoryi str. SP2, Natronobacterium gregoryi strain SP2
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