STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (120 aa)    
Predicted Functional Partners:
EHM52484.1
Aminomethyltransferase; KEGG: dno:DNO_1197 9.0e-128 gcvT; glycine cleavage system T protein K00605; Psort location: Cytoplasmic, score: 9.97.
 
 0.999
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
 
 0.999
EHM51062.1
KEGG: msu:MS1058 3.3e-114 lplA; LplA protein; K03800 lipoate-protein ligase A; Psort location: Cytoplasmic, score: 9.97.
 
 
 0.984
EHM55753.1
Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.
    
 0.951
EHM53954.1
Dihydrolipoyl dehydrogenase; KEGG: dno:DNO_1100 6.1e-209 lpdA; dihydrolipoamide dehydrogenase K00382; Psort location: Cytoplasmic, score: 9.97.
 
 0.947
lipA
Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
 
 
 0.926
lipB
Lipoyl(octanoyl) transferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
   
 0.921
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
 
 
 0.916
tuf
Translation elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.
 
 
    0.890
EHM49882.1
KEGG: alv:Alvin_0293 4.4e-270 2-oxoglutarate dehydrogenase, E1 subunit K00164; Psort location: Cytoplasmic, score: 9.97.
   
 
 0.889
Your Current Organism:
Cardiobacterium valvarum
NCBI taxonomy Id: 797473
Other names: C. valvarum F0432, Cardiobacterium valvarum F0432, Cardiobacterium valvarum str. F0432, Cardiobacterium valvarum strain F0432
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