STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mutMDNA-formamidopyrimidine glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (280 aa)    
Predicted Functional Partners:
polA
DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
  
 0.999
coaE
dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
 
  
 0.996
EHM01452.1
Replication initiation and membrane attachment protein, DnaB/DnaD family; KEGG: bpu:BPUM_2543 1.2e-31 dnaB; replicative DNA helicase K03346; Psort location: Cytoplasmic, score: 8.96.
 
  
 0.904
EHM01451.1
Primosomal protein DnaI; Psort location: Cytoplasmic, score: 8.96.
 
   
 0.870
nrdR
Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family.
  
    0.830
EHM00345.1
GIY-YIG catalytic domain protein; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
 
 
 0.654
EHM00343.1
Hypothetical protein; KEGG: sax:USA300HOU_1082 2.9e-17 uvrC; excinuclease ABC subunit C K03703; Psort location: Cytoplasmic, score: 9.26.
  
 
 0.577
EHM00344.1
KEGG: bay:RBAM_025550 3.9e-40 uvrC; excinuclease ABC subunit C K03703; Psort location: Cytoplasmic, score: 9.97.
  
 
 0.577
EHL97131.1
DEAD/DEAH box helicase; KEGG: lac:LBA0470 2.8e-117 ATP-dependent helicase; K03724 ATP-dependent helicase Lhr and Lhr-like helicase.
  
  
 0.555
EHL97132.1
Hypothetical protein; KEGG: lcr:LCRIS_00478 3.3e-185 lhr; ATP-dependent helicase; K03724 ATP-dependent helicase Lhr and Lhr-like helicase; Psort location: Cytoplasmic, score: 8.96.
  
  
 0.555
Your Current Organism:
Lactobacillus parafarraginis
NCBI taxonomy Id: 797515
Other names: L. parafarraginis F0439, Lactobacillus parafarraginis F0439, Lactobacillus parafarraginis str. F0439, Lactobacillus parafarraginis strain F0439, Lactobacillus sp. oral taxon 418 str. F0439
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.