STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
hprKHPr(Ser) kinase/phosphatase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable car [...] (343 aa)    
Predicted Functional Partners:
EHL99282.1
Phosphocarrier protein HPr; KEGG: lcb:LCABL_19790 7.4e-30 ptsH; phosphocarrier protein HPr K11189; Psort location: Cytoplasmic, score: 9.26.
 
 
 
 0.902
lgt
Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family.
  
  
 0.900
EHM00214.1
Phosphocarrier, HPr family; KEGG: lcb:LCABL_19790 4.9e-17 ptsH; phosphocarrier protein HPr K11189; Psort location: Cytoplasmic, score: 9.97.
 
 
 
 0.791
uvrB
Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
    
 0.778
EHL99283.1
Phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
 
   
 0.773
EHL96077.1
Kinase domain protein; KEGG: lbr:LVIS_0962 3.2e-164 serine/threonine kinase protein; K08884 serine/threonine protein kinase, bacterial; Psort location: CytoplasmicMembrane, score: 9.82.
   
 
 0.739
gpsA
KEGG: lbr:LVIS_0643 2.8e-124 glycerol-3-phosphate dehydrogenase; K00057 glycerol-3-phosphate dehydrogenase (NAD(P)+); Psort location: Cytoplasmic, score: 9.26; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
  
  
 0.729
EHM00624.1
Hypothetical protein; KEGG: lki:LKI_08340 8.0e-17 HPr kinase/phosphorylase K08972; Psort location: CytoplasmicMembrane, score: 10.00.
     
 0.701
EHM00625.1
PspC domain protein; KEGG: bla:BLA_0408 0.0017 possible histidine kinase sensor of two component system; Psort location: CytoplasmicMembrane, score: 9.82.
       0.611
EHM00619.1
KEGG: lbr:LVIS_0645 4.1e-123 thioredoxin reductase; K00384 thioredoxin reductase (NADPH); Psort location: Cytoplasmic, score: 9.97.
     
 0.594
Your Current Organism:
Lactobacillus parafarraginis
NCBI taxonomy Id: 797515
Other names: L. parafarraginis F0439, Lactobacillus parafarraginis F0439, Lactobacillus parafarraginis str. F0439, Lactobacillus parafarraginis strain F0439, Lactobacillus sp. oral taxon 418 str. F0439
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