STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metKMethionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (396 aa)    
Predicted Functional Partners:
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 0.983
EHL96173.1
Methionine synthase, vitamin-B12 independent; KEGG: llm:llmg_1849 3.8e-120 metE2; hypothetical protein K00549; Psort location: Cytoplasmic, score: 8.96.
  
 0.970
EHL95188.1
Hypothetical protein; KEGG: llm:llmg_1849 1.0e-46 metE2; hypothetical protein K00549; Psort location: Cytoplasmic, score: 8.96.
  
 0.943
EHL98934.1
Putative homocysteine S-methyltransferase; KEGG: lpl:lp_1298 1.8e-81 mmuM; homocysteine methyltransferase K00547; Psort location: Cytoplasmic, score: 9.26.
     
 0.925
EHL96243.1
Putative LL-diaminopimelate aminotransferase; KEGG: lpl:lp_0339 2.0e-169 transaminase K08969; Psort location: Cytoplasmic, score: 9.97.
  
 0.915
EHL97912.1
Putative modification methylase HaeIII; KEGG: mmy:MSC_0216 5.1e-102 dcm; cytosine-specific DNA-methyltransferase Sau96I; K00558 DNA (cytosine-5-)-methyltransferase; Psort location: Cytoplasmic, score: 8.96.
    
 0.899
EHM00399.1
Putative LL-diaminopimelate aminotransferase; KEGG: bca:BCE_4102 7.1e-80 transaminase; K08969 aminotransferase; Psort location: Cytoplasmic, score: 9.26.
  
 0.874
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
  
 
 0.838
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.806
EHL95183.1
Hypothetical protein; KEGG: lhe:lhv_1915 4.1e-36 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH); Belongs to the methylenetetrahydrofolate reductase family.
  
 
 0.798
Your Current Organism:
Lactobacillus parafarraginis
NCBI taxonomy Id: 797515
Other names: L. parafarraginis F0439, Lactobacillus parafarraginis F0439, Lactobacillus parafarraginis str. F0439, Lactobacillus parafarraginis strain F0439, Lactobacillus sp. oral taxon 418 str. F0439
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