STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (347 aa)    
Predicted Functional Partners:
ilvD
KEGG: sgo:SGO_2064 3.0e-239 ilvD; dihydroxy-acid dehydratase K01687; Psort location: Cytoplasmic, score: 9.97; Belongs to the IlvD/Edd family.
 
 
 0.994
EHL98527.1
Hypothetical protein; KEGG: lwe:lwe2002 2.1e-39 ilvD; dihydroxy-acid dehydratase K01687; Psort location: Cytoplasmic, score: 9.26.
 
 
 0.990
EHL98528.1
Putative dihydroxy-acid dehydratase; KEGG: lme:LEUM_2040 1.2e-171 dihydroxyacid dehydratase K01687; Psort location: Cytoplasmic, score: 9.97; Belongs to the IlvD/Edd family.
 
 
 0.990
EHL98531.1
KEGG: sha:SH0979 2.5e-148 ilvB; acetolactate synthase large subunit; K01652 acetolactate synthase I/II/III large subunit; Psort location: Cytoplasmic, score: 9.26.
 
 
 0.982
leuC
3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
  
 0.974
leuD
3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
  
 0.914
EHM01617.1
KEGG: ooe:OEOE_1723 1.3e-151 2-isopropylmalate synthase K01649; Psort location: Cytoplasmic, score: 9.97; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
  
 0.911
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
  
 0.911
EHL98027.1
KEGG: lbr:LVIS_0491 5.7e-197 acetolactate synthase K01652; Psort location: Cytoplasmic, score: 9.26; Belongs to the TPP enzyme family.
 
 
 0.879
EHL99763.1
Putative glutamate synthase [NADPH], large subunit; KEGG: lca:LSEI_2556 0. glutamate synthase domain-containing 3; K00265 glutamate synthase (NADPH/NADH) large chain; Psort location: Cytoplasmic, score: 9.26.
  
  
 0.850
Your Current Organism:
Lactobacillus parafarraginis
NCBI taxonomy Id: 797515
Other names: L. parafarraginis F0439, Lactobacillus parafarraginis F0439, Lactobacillus parafarraginis str. F0439, Lactobacillus parafarraginis strain F0439, Lactobacillus sp. oral taxon 418 str. F0439
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