STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
EHO54099.1IMP dehydrogenase / GMP reductase domain protein; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (274 aa)    
Predicted Functional Partners:
EHO51637.1
KEGG: ppe:PEPE_0412 4.1e-123 guaA; GMP synthase K01951; Psort location: Cytoplasmic, score: 9.97; overlaps another CDS with the same product name.
 0.999
EHO51636.1
KEGG: lbr:LVIS_1759 1.1e-99 guaA; GMP synthase K01951; Psort location: Cytoplasmic, score: 9.26; overlaps another CDS with the same product name.
 
 0.997
EHO54098.1
IMP dehydrogenase / GMP reductase domain protein; KEGG: lrl:LC705_00240 1.1e-33 guaB; inosine-5'-monophosphate dehydrogenase; K00088 IMP dehydrogenase; Psort location: Cytoplasmic, score: 9.26.
  
  0.994
purA
Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 
 0.986
purH
KEGG: lpl:lp_2720 4.3e-192 purH; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase K00602; Psort location: Cytoplasmic, score: 9.97.
  
 
 0.974
EHO48590.1
Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
 0.963
guaC
GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.
  
  
 
0.960
xpt
Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
  
 
 0.957
EHO50905.1
KEGG: lbr:LVIS_0522 3.1e-63 hypoxanthine-guanine phosphoribosyltransferase; K00760 hypoxanthine phosphoribosyltransferase; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
 0.882
EHO52803.1
Adenylosuccinate lyase; KEGG: lpj:JDM1_2623 1.7e-174 purB; adenylosuccinate lyase; K01756 adenylosuccinate lyase; Psort location: Cytoplasmic, score: 9.97.
  
  
 0.740
Your Current Organism:
Lactobacillus kisonensis
NCBI taxonomy Id: 797516
Other names: L. kisonensis F0435, Lactobacillus kisonensis F0435, Lactobacillus kisonensis str. F0435, Lactobacillus kisonensis strain F0435, Lactobacillus sp. oral taxon 424 str. F0435
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