STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (215 aa)    
Predicted Functional Partners:
pyrD
Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate.
 
 0.999
pyrF
Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
 
 0.999
pyrC
Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
 
 
 0.998
pyrB
KEGG: lpl:lp_2703 1.6e-98 pyrB; aspartate carbamoyltransferase catalytic subunit K00609; Psort location: Cytoplasmic, score: 9.97; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
 
  
 0.997
EHO48931.1
Uracil permease; KEGG: hiq:CGSHiGG_01870 3.5e-71 upp; uracil phosphoribosyltransferase K02824; Psort location: CytoplasmicMembrane, score: 10.00.
  
  
 0.982
EHO51103.1
Carbamoyl-phosphate synthetase, large subunit, oligomerization domain protein; KEGG: lbr:LVIS_0829 2.1e-208 carbamoylphosphate synthase large subunit; K01955 carbamoyl-phosphate synthase large subunit; Psort location: Cytoplasmic, score: 9.97.
  
 
 0.978
EHO49765.1
KEGG: lfe:LAF_0728 0. carbamoyl-phosphate synthase large subunit; K01955 carbamoyl-phosphate synthase large subunit; Psort location: Cytoplasmic, score: 9.97.
  
 
 0.978
pyrR
Putative pyrimidine operon regulatory protein/uracil phosphoribosyltransferase PyrR; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
  
 
 0.968
prs
Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
  
 
 0.963
prs-2
Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
  
 
 0.963
Your Current Organism:
Lactobacillus kisonensis
NCBI taxonomy Id: 797516
Other names: L. kisonensis F0435, Lactobacillus kisonensis F0435, Lactobacillus kisonensis str. F0435, Lactobacillus kisonensis strain F0435, Lactobacillus sp. oral taxon 424 str. F0435
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