STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EHO50206.1Ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; KEGG: lbr:LVIS_1898 1.1e-280 ribonucleotide reductase, alpha subunit; K00525 ribonucleoside-diphosphate reductase alpha chain. (671 aa)    
Predicted Functional Partners:
EHO52300.1
Ribonucleoside-diphosphate reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family.
  
 0.993
EHO52298.1
Glutaredoxin; KEGG: lre:Lreu_0324 3.2e-22 ribonucleoside-diphosphate reductase class Ib glutaredoxin subunit K06191.
  
 0.980
EHO47003.1
dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
  
 
 0.977
pyrG
CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
   
 
 0.961
EHO48879.1
Pyruvate kinase; KEGG: lbr:LVIS_0765 4.4e-261 pyruvate kinase; K00873 pyruvate kinase; Psort location: Cytoplasmic, score: 9.97.
     
 0.959
folE
GTP cyclohydrolase I; KEGG: lbu:LBUL_0209 5.8e-117 GTP cyclohydrolase I; K00950 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase K01495; Psort location: Cytoplasmic, score: 9.97.
  
 
  0.880
EHO50947.1
Thioredoxin; KEGG: edi:EDI_037950 3.4e-09 thioredoxin-1.
  
 
 0.851
polA
DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
 
 0.784
EHO54270.1
Putative nrdI protein; KEGG: sds:SDEG_0228 4.2e-27 nrdI; flavoprotein NrdI K03647; Psort location: Cytoplasmic, score: 8.96; Belongs to the NrdI family.
  
  
 0.769
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
  
 0.750
Your Current Organism:
Lactobacillus kisonensis
NCBI taxonomy Id: 797516
Other names: L. kisonensis F0435, Lactobacillus kisonensis F0435, Lactobacillus kisonensis str. F0435, Lactobacillus kisonensis strain F0435, Lactobacillus sp. oral taxon 424 str. F0435
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