vir protein (Clonorchis sinensis) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

vir

Protein virilizer. (2252 aa)

Predicted Functional Partners:

THOC2

0.963

CBLL1

0.953

fl(2)d

0.938

CSKR_13441s

0.938

mettl3

0.813

mettl14

0.777

RBM15

0.711

mettl16

0.693

Ythdc2

0.686

cpsf5

0.631

Your Current Organism:

Clonorchis sinensis

NCBI taxonomy Id: 79923
Other names: C. sinensis, oriental liver fluke

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBLL1	CSKR_13441s	A0A419PQT3	A0A419QCF8	E3 ubiquitin-protein ligase Hakai.	Uncharacterized protein.	0.908
CBLL1	RBM15	A0A419PQT3	G7Y8R5	E3 ubiquitin-protein ligase Hakai.	Putative RNA-binding protein 15.	0.552
CBLL1	THOC2	A0A419PQT3	A0A419PGX8	E3 ubiquitin-protein ligase Hakai.	THO complex subunit 2.	0.635
CBLL1	Ythdc2	A0A419PQT3	A0A3R7G994	E3 ubiquitin-protein ligase Hakai.	Putative ATP-dependent RNA helicase YTHDC2.	0.566
CBLL1	cpsf5	A0A419PQT3	A0A3R7DFH1	E3 ubiquitin-protein ligase Hakai.	Cleavage and polyadenylation specificity factor subunit 5.	0.433
CBLL1	fl(2)d	A0A419PQT3	A0A419QC05	E3 ubiquitin-protein ligase Hakai.	Pre-mRNA-splicing regulator female-lethal(2)D.	0.908
CBLL1	mettl14	A0A419PQT3	A0A3R7FLT3	E3 ubiquitin-protein ligase Hakai.	N6-adenosine-methyltransferase subunit METTL14; Belongs to the MT-A70-like family.	0.675
CBLL1	mettl16	A0A419PQT3	A0A3R7FEU2	E3 ubiquitin-protein ligase Hakai.	Methyltransferase-like protein 16.	0.557
CBLL1	mettl3	A0A419PQT3	A0A3R7G8U9	E3 ubiquitin-protein ligase Hakai.	N6-adenosine-methyltransferase subunit METTL3.	0.675
CBLL1	vir	A0A419PQT3	A0A3R7K188	E3 ubiquitin-protein ligase Hakai.	Protein virilizer.	0.953
CSKR_13441s	CBLL1	A0A419QCF8	A0A419PQT3	Uncharacterized protein.	E3 ubiquitin-protein ligase Hakai.	0.908
CSKR_13441s	RBM15	A0A419QCF8	G7Y8R5	Uncharacterized protein.	Putative RNA-binding protein 15.	0.675
CSKR_13441s	THOC2	A0A419QCF8	A0A419PGX8	Uncharacterized protein.	THO complex subunit 2.	0.915
CSKR_13441s	Ythdc2	A0A419QCF8	A0A3R7G994	Uncharacterized protein.	Putative ATP-dependent RNA helicase YTHDC2.	0.647
CSKR_13441s	mettl14	A0A419QCF8	A0A3R7FLT3	Uncharacterized protein.	N6-adenosine-methyltransferase subunit METTL14; Belongs to the MT-A70-like family.	0.891
CSKR_13441s	mettl16	A0A419QCF8	A0A3R7FEU2	Uncharacterized protein.	Methyltransferase-like protein 16.	0.451
CSKR_13441s	mettl3	A0A419QCF8	A0A3R7G8U9	Uncharacterized protein.	N6-adenosine-methyltransferase subunit METTL3.	0.938
CSKR_13441s	vir	A0A419QCF8	A0A3R7K188	Uncharacterized protein.	Protein virilizer.	0.938
RBM15	CBLL1	G7Y8R5	A0A419PQT3	Putative RNA-binding protein 15.	E3 ubiquitin-protein ligase Hakai.	0.552
RBM15	CSKR_13441s	G7Y8R5	A0A419QCF8	Putative RNA-binding protein 15.	Uncharacterized protein.	0.675

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

52

average node degree:

9.45

avg. local clustering coefficient:

0.945

expected number of edges:

16

PPI enrichment p-value:

4.62e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0120255

Olefinic compound biosynthetic process

3 of 14

2.6

2.59

0.00011

GO:0034309

Primary alcohol biosynthetic process

3 of 23

2.38

2.35

0.00021

GO:0042181

Ketone biosynthetic process

3 of 43

2.11

1.91

0.00080

GO:0006351

Transcription, DNA-templated

4 of 201

1.57

1.52

0.00086

GO:0006366

Transcription by RNA polymerase II

3 of 89

1.8

1.47

0.0028

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005665

RNA polymerase II, core complex

3 of 12

2.67

2.94

3.25e-05

GO:0005736

RNA polymerase I complex

2 of 11

2.53

1.71

0.0026

GO:0005666

RNA polymerase III complex

2 of 15

2.39

1.6

0.0036

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:17413

Olefinic compound biosynthetic process

2 of 5

2.87

1.34

0.0103

CL:3460

RNA polymerase II, core complex

2 of 11

2.53

1.15

0.0192

CL:3359

DNA-directed RNA polymerase complex, and Transcription elongation factor complex

3 of 123

1.66

1.0

0.0192

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03020

RNA polymerase

3 of 41

2.13

2.27

0.00018

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-77075

RNA Pol II CTD phosphorylation and interaction with CE

3 of 29

2.28

2.14

0.00041

MAP-72086

mRNA Capping

3 of 31

2.25

2.13

0.00041

MAP-113418

Formation of the Early Elongation Complex

3 of 31

2.25

2.13

0.00041

MAP-9018519

Estrogen-dependent gene expression

3 of 37

2.18

2.1

0.00041

MAP-6796648

TP53 Regulates Transcription of DNA Repair Genes

3 of 39

2.15

2.09

0.00041

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

3 of 73

1.88

1.35

0.0058

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0240

DNA-directed RNA polymerase

3 of 26

2.33

2.58

7.91e-05

KW-0804

Transcription

4 of 208

1.55

1.7

0.00023

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