NPHS1 protein (Clonorchis sinensis) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

NPHS1

Nephrin. (1062 aa)

Predicted Functional Partners:

Tjp1

0.687

Cask

0.674

Mllt4

0.623

Mllt4-2

0.623

rst-2

0.605

CSKR_8866s

0.572

Ptk7

0.553

Iqgap2

0.536

NCK1

0.530

NCK2

0.530

Your Current Organism:

Clonorchis sinensis

NCBI taxonomy Id: 79923
Other names: C. sinensis, oriental liver fluke

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSKR_8866s	NPHS1	A0A3R7CWT9	A0A419PHD7	Uncharacterized protein.	Nephrin.	0.572
CSKR_8866s	Ptk7	A0A3R7CWT9	A0A3R7EWR4	Uncharacterized protein.	Inactive tyrosine-protein kinase 7; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.623
CSKR_8866s	Tjp1	A0A3R7CWT9	A0A3R7F6D4	Uncharacterized protein.	Tight junction protein ZO-1.	0.457
CSKR_8866s	rst-2	A0A3R7CWT9	A0A419QIA9	Uncharacterized protein.	Irregular chiasm C-roughest protein.	0.440
Cask	Iqgap2	A0A419PZV3	A0A3R7CES0	Peripheral plasma membrane protein CASK.	Ras GTPase-activating-like protein IQGAP2.	0.440
Cask	NPHS1	A0A419PZV3	A0A419PHD7	Peripheral plasma membrane protein CASK.	Nephrin.	0.674
Cask	Ptk7	A0A419PZV3	A0A3R7EWR4	Peripheral plasma membrane protein CASK.	Inactive tyrosine-protein kinase 7; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.668
Iqgap2	Cask	A0A3R7CES0	A0A419PZV3	Ras GTPase-activating-like protein IQGAP2.	Peripheral plasma membrane protein CASK.	0.440
Iqgap2	NCK1	A0A3R7CES0	A0A3R7CHB7	Ras GTPase-activating-like protein IQGAP2.	Cytoplasmic protein NCK1.	0.499
Iqgap2	NCK2	A0A3R7CES0	G7YAN8	Ras GTPase-activating-like protein IQGAP2.	Cytoplasmic protein NCK2.	0.499
Iqgap2	NPHS1	A0A3R7CES0	A0A419PHD7	Ras GTPase-activating-like protein IQGAP2.	Nephrin.	0.536
Iqgap2	Tjp1	A0A3R7CES0	A0A3R7F6D4	Ras GTPase-activating-like protein IQGAP2.	Tight junction protein ZO-1.	0.548
Mllt4	NPHS1	A0A3R7FNG2	A0A419PHD7	Afadin.	Nephrin.	0.623
Mllt4	Tjp1	A0A3R7FNG2	A0A3R7F6D4	Afadin.	Tight junction protein ZO-1.	0.891
Mllt4-2	NPHS1	A0A3R7FSZ3	A0A419PHD7	Afadin.	Nephrin.	0.623
Mllt4-2	Tjp1	A0A3R7FSZ3	A0A3R7F6D4	Afadin.	Tight junction protein ZO-1.	0.891
NCK1	Iqgap2	A0A3R7CHB7	A0A3R7CES0	Cytoplasmic protein NCK1.	Ras GTPase-activating-like protein IQGAP2.	0.499
NCK1	NPHS1	A0A3R7CHB7	A0A419PHD7	Cytoplasmic protein NCK1.	Nephrin.	0.530
NCK1	Ptk7	A0A3R7CHB7	A0A3R7EWR4	Cytoplasmic protein NCK1.	Inactive tyrosine-protein kinase 7; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.653
NCK1	rst-2	A0A3R7CHB7	A0A419QIA9	Cytoplasmic protein NCK1.	Irregular chiasm C-roughest protein.	0.603

page 1 of 3

Network Stats

number of nodes:

6

number of edges:

6

average node degree:

2

avg. local clustering coefficient:

0.85

expected number of edges:

5

PPI enrichment p-value:

0.406

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042773

ATP synthesis coupled electron transport

8 of 35

2.59

7.83

1.21e-16

GO:0022900

Electron transport chain

9 of 71

2.33

7.26

6.19e-17

GO:0019646

Aerobic electron transport chain

7 of 31

2.58

6.88

1.64e-14

GO:0042775

Mitochondrial ATP synthesis coupled electron transport

7 of 32

2.57

6.85

1.71e-14

GO:0006122

Mitochondrial electron transport, ubiquinol to cytochrome c

4 of 9

2.88

4.21

1.59e-08

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015453

Oxidoreduction-driven active transmembrane transporter activity

7 of 40

2.47

6.2

2.16e-13

GO:0009055

Electron transfer activity

7 of 65

2.26

5.36

2.52e-12

GO:0008121

Ubiquinol-cytochrome-c reductase activity

3 of 8

2.8

2.84

5.95e-06

GO:0015078

Proton transmembrane transporter activity

5 of 101

1.93

2.75

7.97e-07

GO:0022853

Active ion transmembrane transporter activity

5 of 150

1.75

2.28

4.52e-06

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070469

Respirasome

10 of 58

2.47

9.39

1.87e-21

GO:0070069

Cytochrome complex

6 of 16

2.8

6.93

5.47e-14

GO:0005746

Mitochondrial respirasome

7 of 46

2.41

6.4

3.86e-14

GO:0098803

Respiratory chain complex

7 of 47

2.4

6.38

3.88e-14

GO:0098800

Inner mitochondrial membrane protein complex

7 of 83

2.16

5.25

1.08e-12

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:22310

Cytochrome complex, and Peptidase M16, zinc-binding site

9 of 20

2.88

10.62

1.90e-21

CL:22312

Cytochrome complex

6 of 12

2.93

7.22

2.41e-14

CL:22338

Mitochondrial electron transport, ubiquinol to cytochrome c

3 of 5

3.01

3.22

1.34e-06

CL:22315

Mitochondrial respiratory chain complex IV

3 of 6

2.93

3.12

1.90e-06

CL:5987

NADH dehydrogenase complex

2 of 20

2.23

1.07

0.0102

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

11 of 158

2.07

7.29

3.55e-21

map01100

Metabolic pathways

11 of 4972

0.58

0.51

3.58e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-611105

Respiratory electron transport

11 of 70

2.43

10.13

4.69e-24

MAP-163200

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

11 of 81

2.36

9.67

1.04e-23

MAP-1428517

The citric acid (TCA) cycle and respiratory electron transport

11 of 201

1.97

6.36

9.64e-20

MAP-9707564

Cytoprotection by HMOX1

3 of 28

2.26

2.03

0.00013

MAP-5628897

TP53 Regulates Metabolic Genes

3 of 39

2.12

1.83

0.00027

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070069

Cytochrome complex

4 of 9

2.88

4.4

6.80e-09

GOCC:0005743

Mitochondrial inner membrane

8 of 185

1.87

4.13

9.14e-12

GOCC:0005746

Mitochondrial respirasome

4 of 18

2.58

3.84

4.85e-08

GOCC:0098803

Respiratory chain complex

4 of 22

2.49

3.68

8.26e-08

GOCC:0098798

Mitochondrial protein complex

7 of 187

1.8

3.46

7.57e-10

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0679

Respiratory chain

2 of 8

2.63

1.35

0.0035

KW-0830

Ubiquinone

2 of 17

2.3

1.18

0.0066

KW-0999

Mitochondrion inner membrane

2 of 40

1.93

0.93

0.0165

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF05193

Peptidase M16 inactive domain

3 of 6

2.93

2.64

1.52e-05

PF00675

Insulinase (Peptidase family M16)

3 of 6

2.93

2.64

1.52e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR011765

Peptidase M16, N-terminal

3 of 6

2.93

2.41

4.09e-05

IPR011249

Metalloenzyme, LuxS/M16 peptidase-like

3 of 6

2.93

2.41

4.09e-05

IPR007863

Peptidase M16, C-terminal

3 of 6

2.93

2.41

4.09e-05

IPR001431

Peptidase M16, zinc-binding site

2 of 2

3.23

1.57

0.0015

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