STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Gpc4Glypican-4; Belongs to the glypican family. (589 aa)    
Predicted Functional Partners:
fzd7
Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.926
Fzd10
Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.920
fzd8
Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.920
fzd8-2
Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.912
FZD10
Frizzled-10.
    
 0.912
Sdc
Syndecan.
    
 0.749
notum
Palmitoleoyl-protein carboxylesterase NOTUM.
    
 0.704
dhh-a
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
    
 0.668
ndst1
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1.
    
 0.617
hs6st1a
Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
     
 0.593
Your Current Organism:
Clonorchis sinensis
NCBI taxonomy Id: 79923
Other names: C. sinensis, oriental liver fluke
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.