MYO2 protein (Clonorchis sinensis) - STRING interaction network

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

MYO2

Myosin-2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (797 aa)

Predicted Functional Partners:

RABA1A

0.789

RABA1C

0.789

RABL2A

0.789

CSKR_2415s

0.789

lrk-1

0.778

LATS1

0.727

EXOC4

0.726

CSKR_1531s

0.719

ACTR3

0.716

CFAP70

0.714

Your Current Organism:

Clonorchis sinensis

NCBI taxonomy Id: 79923
Other names: C. sinensis, oriental liver fluke

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTR3	MYO2	H2KVF0	A0A419Q8E8	Actin-related protein 3; Belongs to the actin family.	Myosin-2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.716
ACTR3	lrk-1	H2KVF0	A0A3R7DIY7	Actin-related protein 3; Belongs to the actin family.	Leucine-rich repeat serine/threonine-protein kinase 1.	0.745
CFAP70	CSKR_1531s	A0A3R7CLR5	A0A3R7CYD6	Cilia-and flagella-associated protein 70.	Sec2p domain-containing protein.	0.611
CFAP70	EXOC4	A0A3R7CLR5	A0A3R7G861	Cilia-and flagella-associated protein 70.	Exocyst complex component 4.	0.549
CFAP70	MYO2	A0A3R7CLR5	A0A419Q8E8	Cilia-and flagella-associated protein 70.	Myosin-2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.714
CFAP70	lrk-1	A0A3R7CLR5	A0A3R7DIY7	Cilia-and flagella-associated protein 70.	Leucine-rich repeat serine/threonine-protein kinase 1.	0.898
CSKR_1531s	CFAP70	A0A3R7CYD6	A0A3R7CLR5	Sec2p domain-containing protein.	Cilia-and flagella-associated protein 70.	0.611
CSKR_1531s	CSKR_2415s	A0A3R7CYD6	A0A419QF96	Sec2p domain-containing protein.	Ras-related protein Rab-11B.	0.924
CSKR_1531s	EXOC4	A0A3R7CYD6	A0A3R7G861	Sec2p domain-containing protein.	Exocyst complex component 4.	0.855
CSKR_1531s	MYO2	A0A3R7CYD6	A0A419Q8E8	Sec2p domain-containing protein.	Myosin-2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.719
CSKR_1531s	RABA1A	A0A3R7CYD6	A0A3R7FJP2	Sec2p domain-containing protein.	Ras-related protein RABA1a.	0.924
CSKR_1531s	RABA1C	A0A3R7CYD6	A0A3R7GQ11	Sec2p domain-containing protein.	Ras-related protein RABA1c.	0.924
CSKR_1531s	RABL2A	A0A3R7CYD6	A0A419PJG2	Sec2p domain-containing protein.	Rab-like protein 2A.	0.862
CSKR_2415s	CSKR_1531s	A0A419QF96	A0A3R7CYD6	Ras-related protein Rab-11B.	Sec2p domain-containing protein.	0.924
CSKR_2415s	EXOC4	A0A419QF96	A0A3R7G861	Ras-related protein Rab-11B.	Exocyst complex component 4.	0.748
CSKR_2415s	MYO2	A0A419QF96	A0A419Q8E8	Ras-related protein Rab-11B.	Myosin-2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.789
CSKR_2415s	lrk-1	A0A419QF96	A0A3R7DIY7	Ras-related protein Rab-11B.	Leucine-rich repeat serine/threonine-protein kinase 1.	0.902
EXOC4	CFAP70	A0A3R7G861	A0A3R7CLR5	Exocyst complex component 4.	Cilia-and flagella-associated protein 70.	0.549
EXOC4	CSKR_1531s	A0A3R7G861	A0A3R7CYD6	Exocyst complex component 4.	Sec2p domain-containing protein.	0.855
EXOC4	CSKR_2415s	A0A3R7G861	A0A419QF96	Exocyst complex component 4.	Ras-related protein Rab-11B.	0.748

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

30

average node degree:

5.45

avg. local clustering coefficient:

0.899

expected number of edges:

16

PPI enrichment p-value:

0.00167

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000077

DNA damage checkpoint signaling

3 of 19

2.26

1.44

0.0020

GO:0035556

Intracellular signal transduction

5 of 207

1.44

1.14

0.0020

GO:0007017

Microtubule-based process

3 of 78

1.64

0.93

0.0125

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005200

Structural constituent of cytoskeleton

3 of 6

2.76

2.27

6.71e-05

GO:0005509

Calcium ion binding

3 of 68

1.7

0.87

0.0188

GO:0005525

GTP binding

3 of 129

1.42

0.71

0.0313

GO:0004674

Protein serine/threonine kinase activity

3 of 152

1.35

0.66

0.0378

GO:0035639

Purine ribonucleoside triphosphate binding

6 of 896

0.88

0.55

0.0188

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005856

Cytoskeleton

6 of 258

1.42

1.62

2.93e-05

GO:0005874

Microtubule

3 of 57

1.78

1.27

0.0025

GO:0015630

Microtubule cytoskeleton

4 of 140

1.51

1.17

0.0022

GO:0099080

Supramolecular complex

4 of 158

1.46

1.13

0.0023

GO:0043232

Intracellular non-membrane-bounded organelle

7 of 1135

0.85

0.66

0.0025

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2438

Tubulin, and Kinetochore adaptor activity

5 of 5

3.06

5.46

8.66e-11

CL:3119

Mixed, incl. EF-hand domain, and Calmodulin binding

3 of 21

2.21

1.78

0.00039

CL:9794

Sensing of DNA Double Strand Breaks, and G2/M DNA damage checkpoint

2 of 13

2.24

1.02

0.0129

CL:3120

Mixed, incl. Myosin II complex, and Actin filament bundle

2 of 14

2.21

1.01

0.0135

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04145

Phagosome

4 of 66

1.84

2.02

4.41e-05

map04070

Phosphatidylinositol signaling system

3 of 48

1.85

1.52

0.00079

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9668328

Sealing of the nuclear envelope (NE) by ESCRT-III

4 of 16

2.46

3.06

1.44e-06

MAP-5617833

Cilium Assembly

4 of 29

2.2

2.71

4.03e-06

MAP-75035

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

3 of 7

2.69

2.66

1.20e-05

MAP-2995410

Nuclear Envelope (NE) Reassembly

4 of 42

2.04

2.39

1.20e-05

MAP-1852241

Organelle biogenesis and maintenance

4 of 46

2.0

2.36

1.20e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005823

Central plaque of spindle pole body

3 of 3

3.06

2.75

1.01e-05

GOCC:0005856

Cytoskeleton

6 of 221

1.49

1.82

1.01e-05

GOCC:0015630

Microtubule cytoskeleton

4 of 131

1.54

1.27

0.0013

GOCC:0043232

Intracellular non-membrane-bounded organelle

7 of 1061

0.88

0.71

0.0015

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0493

Microtubule

3 of 16

2.33

2.06

0.00012

KW-0206

Cytoskeleton

3 of 19

2.26

2.04

0.00012

KW-0342

GTP-binding

3 of 56

1.79

1.39

0.0013

KW-0106

Calcium

2 of 40

1.76

0.79

0.0285

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR037103

Tubulin/FtsZ-like, C-terminal domain

3 of 4

2.93

2.36

5.02e-05

IPR023123

Tubulin, C-terminal

3 of 4

2.93

2.36

5.02e-05

IPR018316

Tubulin/FtsZ, 2-layer sandwich domain

3 of 4

2.93

2.36

5.02e-05

IPR017975

Tubulin, conserved site

3 of 4

2.93

2.36

5.02e-05

IPR008280

Tubulin/FtsZ, C-terminal

3 of 4

2.93

2.36

5.02e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00865

Tubulin/FtsZ family, C-terminal domain

3 of 4

2.93

2.86

5.82e-06

SM00864

Tubulin/FtsZ family, GTPase domain

3 of 4

2.93

2.86

5.82e-06

SM00240

Forkhead associated domain

2 of 10

2.36

1.24

0.0051

SM00054

EF-hand, calcium binding motif

2 of 16

2.15

1.1

0.0088

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