Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADL57743.1Predicted NADH dehydrogenase. (149 aa)    
Predicted Functional Partners:
ADL57744.1
Predicted NADH dehydrogenase.
 0.999
ehbL
Energy-converting hydrogenase B, subunit L.
  
 0.993
ADL58149.1
Predicted glutamate synthase, large subunit; Belongs to the glutamate synthase family.
   
 
 0.981
fdhA1
Predicted formate dehydrogenase, alpha chain.
 
 0.969
tfrA
Thiol:fumarate reductase, subunit A; Catalyzes the reduction of fumarate with reduced coenzyme M (CoM-S-H) and coenzyme B (CoB-S-H). In vitro, is able to reduces fumarate with reduced benzyl viologen, oxidize CoM-S-H and CoB-S-H to CoM-S-S-CoB with methylene blue, and reduce CoM-S-S-CoB with reduced benzyl viologen. The enzyme has specificity for the two thiol compounds as the CoB--CoM heterodisulfide reductase. The enzyme is very sensitive to oxygen; Belongs to the FAD-dependent oxidoreductase 2 family.
  
 
 0.926
mobB
Predicted molybdopterin-guanine dinucleotide biosynthesis protein B.
     
 0.904
iorA
Indolepyruvate oxidoreductase, subunit alpha; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
   
 
 0.880
dnaJ
Chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...]
   
 0.853
ADL57997.1
Conserved hypothetical protein containing a ferredoxin domain.
  
 
 0.843
mvhG
F420-non-reducing hydrogenase, subunit G; Part of a complex that provides reducing equivalents for heterodisulfide reductase; Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
   
 
 0.805
Your Current Organism:
Methanothermobacter marburgensis
NCBI taxonomy Id: 79929
Other names: M. marburgensis str. Marburg, Methanobacterium thermoautotrophicum (strain Marburg / DSM 2133), Methanobacterium thermoautotrophicum str. Marburg, Methanothermobacter marburgensis str. Marburg, Methanothermobacter marburgensis strain Marburg
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